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Simon Knott

Cornell University · US
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Area of research
Molecular Biology · Oncology
Research interest
Research interests include Cancer Immunotherapy and Biomarkers, Single-cell and spatial transcriptomics, Epigenetics and DNA Methylation, and DNA Repair Mechanisms.
h-index
31
citations
4,551
works
119
NIH funding
primary concept
Medicine
email

Recent publications

Concurrent loss of the Y chromosome in cancer and T cells impacts outcome
Nature 2025cited by 24position: middledoi
IL-17A-secreting γδ T cells promote resistance to CDK4/CDK6 inhibitors in HR+HER2− breast cancer via CX3CR1+ macrophages
Nature Cancer 2025cited by 20position: middledoi
Lesion-remote astrocytes govern microglia-mediated white matter repair
Nature 2025cited by 5position: middledoi
The molecular consequences of androgen activity in the human breast
Cell Genomics 2023cited by 37position: lastdoi
Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth
Cell Metabolism 2021cited by 271position: middledoi
Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain
Nature Cancer 2021cited by 130position: middledoi
Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans
Cell 2020cited by 404position: middledoi
Lymph node metastases develop through a wider evolutionary bottleneck than distant metastases
Nature Genetics 2020cited by 125position: middledoi
Characterization of universal features of partially methylated domains across tissues and species
Epigenetics & Chromatin 2020cited by 34position: middledoi
lncRNA Spehd Regulates Hematopoietic Stem and Progenitor Cells and Is Required for Multilineage Differentiation
Cell Reports 2019cited by 44position: middledoi
Asparagine bioavailability governs metastasis in a model of breast cancer
Nature 2018cited by 551position: firstdoi
COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors
Journal of Clinical Investigation 2018cited by 56position: middledoi
LncRNA <i>Spehd</i> regulates hematopoietic stem cells and progenitors and is required for multilineage differentiation
bioRxiv (Cold Spring Harbor Laboratory) 2018cited by 0position: middledoi
lncRNA requirements for mouse acute myeloid leukemia and normal differentiation
eLife 2017cited by 69position: middledoi
Author response: lncRNA requirements for mouse acute myeloid leukemia and normal differentiation
2017cited by 1position: middledoi
A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis
Nature 2015cited by 458position: lastdoi
A Computational Algorithm to Predict shRNA Potency
Molecular Cell 2014cited by 98position: firstdoi
Male-specific Fruitless isoforms have different regulatory roles conferred by distinct zinc finger DNA binding domains
BMC Genomics 2013cited by 75position: middledoi
The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis
Nature 2012cited by 337position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Gregory J. Hannon · University of Cambridge10 papers (2012–2020)Nicolas Erard · Cancer Research UK Cambridge Center7 papers (2014–2019)M. Joaquina Delás · The Francis Crick Institute4 papers (2017–2019)Ester Munera-Maravilla · Cancer Research UK Cambridge Center4 papers (2017–2019)Tatjana Kovačević · Cancer Research UK Cambridge Center4 papers (2017–2019)Benjamin T. Jackson · University of California, Berkeley4 papers (2017–2019)Elvin Wagenblast · Icahn School of Medicine at Mount Sinai4 papers (2014–2020)Andrew D. Smith · University of Southern California4 papers (2015–2020)Eva Maria Stork · Cancer Research UK Cambridge Center4 papers (2017–2019)Sophia A. Wild · Novartis (Switzerland)4 papers (2017–2019)Sun Y. Kim · Cold Spring Harbor Laboratory3 papers (2014–2018)Ashley R. Maceli · Cold Spring Harbor Laboratory3 papers (2014–2018)Steffen Dickopf · Roche (Switzerland)2 papers (2015–2018)Annika L. Gable · University of Zurich2 papers (2015–2018)David R. Kelley · Caucaseco Scientific Research Center2 papers (2017–2017)Egor Dolzhenko · Pacific Biosciences (United States)2 papers (2017–2017)John L. Rinn · University of Colorado Boulder2 papers (2017–2017)John E. Wilkinson · Cold Spring Harbor Laboratory2 papers (2015–2018)Inês Amorim Monteiro Barbosa · Novartis (Switzerland)2 papers (2017–2017)Mar Soto · Hospital General Universitario Morales Meseguer2 papers (2015–2018)
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