Area of research
Geriatrics and Gerontology · Physiology
Research interest
Research focused on Sirtuin and Metabolism, with related work in Cancer, Albuminuria, Huntingtin. Notable publications include 'The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling', 'SIRT1 and other sirtuins in metabolism', and 'SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging'.
Human trials exploring anti-aging medicines
Elevated homocysteine is associated with increased rates of epigenetic aging in a population with mild cognitive impairment
Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial
Safety Assessment of High-Purity, Synthetic Nicotinamide Riboside (NR-E) in a 90-Day Repeated Dose Oral Toxicity Study, With a 28-Day Recovery Arm
NAD <sup>+</sup> supplementation rejuvenates aged gut adult stem cells
Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging
DEP domain–containing mTOR–interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute‐on‐chronic liver injury in alcoholic liver disease
SIRT1 deacetylase in aging‐induced neuromuscular degeneration and amyotrophic lateral sclerosis
Sirtuins, NAD + , Aging, and Disease
IMPAIRMENT OF AN ENDOTHELIAL NAD+-H2S SIGNALING NETWORK IS A REVERSIBLE CAUSE OF VASCULAR AGING
The brain, sirtuins, and ageing
Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study
Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota
It takes two to tango: NAD+ and sirtuins in aging/longevity control
mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction
Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway
The multifaceted functions of sirtuins in cancer
SIRT1 and other sirtuins in metabolism
Muscle-Specific SIRT1 Gain-of-Function Increases Slow-Twitch Fibers and Ameliorates Pathophysiology in a Mouse Model of Duchenne Muscular Dystrophy
SirT1 is required in the male germ cell for differentiation and fecundity in mice
SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism
SnapShot: Sirtuins, NAD, and Aging
Aging Research—Where Do We Stand and Where Are We Going?
The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging
Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes
Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21
SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin
Sirtuin deacetylases in neurodegenerative diseases of aging