Area of research
Molecular Biology · Cellular and Molecular Neuroscience
Research interest
Research interests include Receptor Mechanisms and Signaling, Neuropeptides and Animal Physiology, Protein Kinase Regulation and GTPase Signaling, and Mass Spectrometry Techniques and Applications.
GPR3 Ligands Discovered through Combined Virtual and Conformational Biosensor-Based Screening
A molecular mechanism to diversify Ca2+ signaling downstream of Gs protein-coupled receptors
Cryo-EM structure of cell-free synthesized human histamine 2 receptor/Gs complex in nanodisc environment
The dark sides of the GPCR tree ‐ research progress on understudied GPCRs
WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction
Development of Fluorescent AF64394 Analogues Enables Real-Time Binding Studies for the Orphan Class A GPCR GPR3
Shedding Light on the D<sub>1</sub>‐Like Receptors: A Fluorescence‐Based Toolbox for Visualization of the D<sub>1</sub> and D<sub>5</sub> Receptors**
Fluorescent Tools for the Imaging of Dopamine D<sub>2</sub>‐Like Receptors**
Fluorescent Tools for Imaging and Ligand Screening of Dopamine D <sub>2</sub> -Like Receptors
Cryo-EM structure of cell-free synthesized human histamine H <sub>2</sub> receptor coupled to heterotrimeric G <sub>s</sub> protein in lipid nanodisc environment
Shedding Light on the D <sub>1</sub> -Like Receptors: A Fluorescence-Based Toolbox for Visualization of the D <sub>1</sub> and D <sub>5</sub> Receptors
Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and mediate intracellular pathway bias
Optical control of the β2-adrenergic receptor with opto-prop-2: A cis-active azobenzene analog of propranolol
Quantitative assessment of constitutive G protein–coupled receptor activity with BRET-based G protein biosensors
A guide to adhesion GPCR research
Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs
A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H<sub>3</sub> Receptor
eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled
Development of a Conformational Histamine H<sub>3</sub> Receptor Biosensor for the Synchronous Screening of Agonists and Inverse Agonists