Area of research
Molecular Biology · Cellular and Molecular Neuroscience
Research interest
Research focused on G protein-coupled receptor and Heterotrimeric G protein, with related work in Receptor, G protein, Signal transduction. Notable publications include 'Structure of the µ-opioid receptor–Gi protein complex', 'Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling', and 'Yeast surface display platform for rapid discovery of conformationally selective nanobodies'.
GPR3 Ligands Discovered through Combined Virtual and Conformational Biosensor-Based Screening
Time-resolved cryo-EM of G-protein activation by a GPCR
Cryo-EM structure of cell-free synthesized human histamine 2 receptor/Gs complex in nanodisc environment
Cryo-EM structure of cell-free synthesized human histamine H <sub>2</sub> receptor coupled to heterotrimeric G <sub>s</sub> protein in lipid nanodisc environment
Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide
Viewing rare conformations of the β <sub>2</sub> adrenergic receptor with pressure-resolved DEER spectroscopy
Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex
Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations
Structure of the µ-opioid receptor–Gi protein complex
Yeast surface display platform for rapid discovery of conformationally selective nanobodies
Development of an antibody fragment that stabilizes GPCR/G-protein complexes
Structural mechanisms of selectivity and gating in anion channelrhodopsins
Single-molecule analysis of ligand efficacy in β2AR–G-protein activation
Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling
Structural basis for nucleotide exchange in heterotrimeric G proteins
Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide