Area of research
Molecular Biology · Cellular and Molecular Neuroscience
Research interest
Research interests include Receptor Mechanisms and Signaling, Protein Structure and Dynamics, Neuropeptides and Animal Physiology, and Computational Drug Discovery Methods.
RNA-Puzzles Round V: blind predictions of 23 RNA structures
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway
A positively tuned voltage indicator for extended electrical recordings in the brain
Structural basis for ion selectivity in potassium-selective channelrhodopsins
Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD
Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine
Autoantibody mimicry of hormone action at the thyrotropin receptor
Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator
Structure and mechanism of the SGLT family of glucose transporters
Selective G protein signaling driven by substance P–neurokinin receptor dynamics
Leveraging nonstructural data to predict structures and affinities of protein–ligand complexes
A positively Tuned Voltage Indicator Reveals Electrical Correlates of Calcium Activity in the Brain
Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms
Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR
Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor
Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex
Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations
Smoothened stimulation by membrane sterols drives Hedgehog pathway activity
Molecular Dynamics Simulation for All
Structure of the µ-opioid receptor–Gi protein complex
Catalytic activation of β-arrestin by GPCRs
Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist
Crystal structure of the natural anion-conducting channelrhodopsin GtACR1
Structural mechanisms of selectivity and gating in anion channelrhodopsins
G<sub>i</sub>- and G<sub>s</sub>-coupled GPCRs show different modes of G-protein binding
Crystal Structure of an LSD-Bound Human Serotonin Receptor
Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors
D<sub>4</sub>dopamine receptor high-resolution structures enable the discovery of selective agonists
Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure