Area of research
Molecular Biology · Radiology, Nuclear Medicine and Imaging
Research interest
Research interests include Receptor Mechanisms and Signaling, Monoclonal and Polyclonal Antibodies Research, Neuropeptides and Animal Physiology, and Bacterial Genetics and Biotechnology.
A DNA-gated molecular guard controls bacterial Hailong anti-phage defence
<i>In silico</i> discovery of nanobody binders to a G-protein coupled receptor using AlphaFold-Multimer
The hit-and-run of cell wall synthesis: LpoB transiently binds and activates PBP1b through a conserved allosteric switch
AlphaFold2 structures guide prospective ligand discovery
Antibodies expand the scope of angiotensin receptor pharmacology
Tetraspanins: structure, dynamics, and principles of partner-protein recognition
Allosteric activation of cell wall synthesis during bacterial growth
Protein design and variant prediction using autoregressive generative models
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2
Structures of the σ2 receptor enable docking for bioactive ligand discovery
Rapid generation of potent antibodies by autonomous hypermutation in yeast
Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR
Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor
Structural coordination of polymerization and crosslinking by a SEDS–bPBP peptidoglycan synthase complex
Synthetic nanobodies as angiotensin receptor blockers
FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein
A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology
Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody
Structural basis for KCTD-mediated rapid desensitization of GABAB signalling
Yeast surface display platform for rapid discovery of conformationally selective nanobodies
A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery
Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling
Structure-based discovery of selective positive allosteric modulators of antagonists for the M <sub>2</sub> muscarinic acetylcholine receptor
Structure and mutagenic analysis of the lipid II flippase MurJ from <i>Escherichia coli</i>
Multidimensional Tracking of GPCR Signaling via Peroxidase-Catalyzed Proximity Labeling
Identification of the gene that codes for the σ<sub>2</sub>receptor
Structural Basis for G Protein-Coupled Receptor Activation
SEDS proteins are a widespread family of bacterial cell wall polymerases
Crystal structure of the human σ1 receptor
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation