Binyue Zhang

Area of research

Environmental Engineering · Pathology and Forensic Medicine

Research interest

Research topics from publications: A Multifunctional Nanoreactor‐Induced Dual Inhibition of HSP70 Strategy for Enhancing Mild Photothermal/Chemodynamic Synergistic Tumor Therapy; The cellular composition of the tumor microenvironment is an important marker for predicting therapeutic efficacy in breast cancer; Radiomics nomogram for predicting axillary lymph node metastasis in breast cancer based on DCE-MRI: A multicenter study; HCC portal hypertension imaging score derived from CT predicts re-bleeding and mortality after acute variceal bleeding. Representative work: Abstract Mild photothermal therapy (PTT) is a spatiotemporally controllable method that utilizes the photothermal effect at relatively low temperatures (40–45 °C) to especially eliminate tumor tissues with negligible side effects on the surrounding normal tissues. However, the overexpression of heat shock protein 70 (HSP70) and limited effect of single treatment drastically impede the therapeutic efficacy. Herein, the constructed multifunctional core‐shell structured Ag‐Cu@SiO 2 ‐PDA/GOx nanoreactors (APG NRs) that provide a dual inhibition of HSP70 strategy for the second near‐infrared photoacoustic (NIR‐II PA) imaging‐guided combined mild PTT/chemodynamic therapy (CDT). The Ag‐Cu cores can At present, the incidence rate of breast cancer ranks first among new-onset malignant tumors in women. The tumor microenvironment is a hot topic in tumor research. There are abundant cells in the tumor microenvironment that play a protumor or antitumor role in breast cancer. During the treatment of breast cancer, different cells have different influences on the therapeutic response. And after treatment, the cellular composition in the tumor microenvironment will change too. In this review, we summarize the interactions between different cell compositions (such as immune cells, fibroblasts, endothelial cells, and adipocytes) in the tumor microenvironment and the treatment mechanism of breast

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