Area of research
Cellular and Molecular Neuroscience · Neurology
Research interest
Research interests include Genetic Neurodegenerative Diseases, Genetic Associations and Epidemiology, Mitochondrial Function and Pathology, and Parkinson's Disease Mechanisms and Treatments.
Genomewide Association Studies of <scp> <i>LRRK2</i> </scp> Modifiers of Parkinson's Disease
A glycomics and proteomics study of aging and Parkinson’s disease in human brain
The caudate nucleus undergoes dramatic and unique transcriptional changes in human prodromal Huntington’s disease brain
Genetic Risk Underlying Psychiatric and Cognitive Symptoms in Huntington’s Disease
Functional variants in the <i>LRRK2</i> gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function
Evidence for a Pan-Neurodegenerative Disease Response in Huntington's and Parkinson's Disease Expression Profiles
The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients
A modifier of Huntington's disease onset at the MLH1 locus
MicroRNAs in CSF as prodromal biomarkers for Huntington disease in the PREDICT-HD study
Evaluation of logistic regression models and effect of covariates for case–control study in RNA-Seq analysis
Haplotype-based stratification of Huntington's disease
Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
microRNA Profiles in Parkinson's Disease Prefrontal Cortex
DNM3 and genetic modifiers of age of onset in LRRK2 Gly2019Ser parkinsonism: a genome-wide linkage and association study
Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of <i>SLC1A3</i> and <i>EPHB2</i>
Novel microRNA discovery using small RNA sequencing in post-mortem human brain
The 4p16.3 Parkinson Disease Risk Locus Is Associated with GAK Expression and Genes Involved with the Synaptic Vesicle Membrane
RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression
miR-10b-5p expression in Huntington’s disease brain relates to age of onset and the extent of striatal involvement
Integrative analyses of proteomics and RNA transcriptomics implicate mitochondrial processes, protein folding pathways and GWAS loci in Parkinson disease
The Role of H3K4me3 in Transcriptional Regulation Is Altered in Huntington’s Disease
Study of plasma‐derived miRNAs mimic differences in Huntington's disease brain
The Genetic Modifiers of Motor OnsetAge (GeM MOA) Website: Genome-wide Association Analysis for Genetic Modifiers of Huntington’s Disease
Sequence-Level Analysis of the Major European Huntington Disease Haplotype
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
MicroRNAs Located in the Hox Gene Clusters Are Implicated in Huntington's Disease Pathogenesis
Conserved Higher-Order Chromatin Regulates NMDA Receptor Gene Expression and Cognition
Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains