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Jan H.M. Schellens

University of Applied Sciences Utrecht · NL
Area of research
Oncology · Molecular Biology
Research interest
Research interests include Colorectal Cancer Treatments and Studies, Cancer Treatment and Pharmacology, Cancer therapeutics and mechanisms, and Lung Cancer Treatments and Mutations.
h-index
112
citations
59,572
works
1,186
NIH funding
primary concept
email

Recent publications

A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in <i>BRAF</i> <i>V600</i> -Mutated Melanoma
Clinical Cancer Research 2024cited by 12position: middledoi
Discovering novel germline genetic variants linked to severe fluoropyrimidine-related toxicity in- and outside DPYD
Genome Medicine 2024cited by 11position: middledoi
A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in BRAFV600-Mutated Melanoma.
2024cited by 7position: contributordoi
Supplementary Fig. S7 from A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;&lt;i&gt;V600&lt;/i&gt;&lt;/sup&gt;-Mutated Melanoma
2024cited by 0position: contributordoi
Data from A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;&lt;i&gt;V600&lt;/i&gt;&lt;/sup&gt;-Mutated Melanoma
2024cited by 0position: contributordoi
Supplementary Fig. S6 from A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;&lt;i&gt;V600&lt;/i&gt;&lt;/sup&gt;-Mutated Melanoma
2024cited by 0position: contributordoi
Supplementary Table S2 from A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;&lt;i&gt;V600&lt;/i&gt;&lt;/sup&gt;-Mutated Melanoma
2024cited by 0position: contributordoi
Supplementary Fig. S2 from A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;&lt;i&gt;V600&lt;/i&gt;&lt;/sup&gt;-Mutated Melanoma
2024cited by 0position: contributordoi
Supplementary Fig. S5 from A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;&lt;i&gt;V600&lt;/i&gt;&lt;/sup&gt;-Mutated Melanoma
2024cited by 0position: contributordoi
Supplementary Fig. S4 from A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;&lt;i&gt;V600&lt;/i&gt;&lt;/sup&gt;-Mutated Melanoma
2024cited by 0position: contributordoi
Supplementary Table S1 from A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;&lt;i&gt;V600&lt;/i&gt;&lt;/sup&gt;-Mutated Melanoma
2024cited by 0position: contributordoi
Supplementary Fig. S5 from A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;&lt;i&gt;V600&lt;/i&gt;&lt;/sup&gt;-Mutated Melanoma
2024cited by 0position: contributordoi
Supplementary Fig. S7 from A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;&lt;i&gt;V600&lt;/i&gt;&lt;/sup&gt;-Mutated Melanoma
2024cited by 0position: contributordoi
Supplementary Fig. S3 from A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;&lt;i&gt;V600&lt;/i&gt;&lt;/sup&gt;-Mutated Melanoma
2024cited by 0position: contributordoi
Supplementary Fig. S1 from A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;&lt;i&gt;V600&lt;/i&gt;&lt;/sup&gt;-Mutated Melanoma
2024cited by 0position: contributordoi
Supplementary Table S3 from A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;&lt;i&gt;V600&lt;/i&gt;&lt;/sup&gt;-Mutated Melanoma
2024cited by 0position: contributordoi
Supplementary Fig. S2 from A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;&lt;i&gt;V600&lt;/i&gt;&lt;/sup&gt;-Mutated Melanoma
2024cited by 0position: contributordoi
Supplementary Fig. S3 from A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;&lt;i&gt;V600&lt;/i&gt;&lt;/sup&gt;-Mutated Melanoma
2024cited by 0position: contributordoi
Supplementary Fig. S1 from A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;&lt;i&gt;V600&lt;/i&gt;&lt;/sup&gt;-Mutated Melanoma
2024cited by 0position: contributordoi
Supplementary Fig. S6 from A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;&lt;i&gt;V600&lt;/i&gt;&lt;/sup&gt;-Mutated Melanoma
2024cited by 0position: contributordoi
Supplementary Fig. S4 from A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;&lt;i&gt;V600&lt;/i&gt;&lt;/sup&gt;-Mutated Melanoma
2024cited by 0position: contributordoi
Data from A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;&lt;i&gt;V600&lt;/i&gt;&lt;/sup&gt;-Mutated Melanoma
2024cited by 0position: contributordoi
Supplementary Table S1 from A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;&lt;i&gt;V600&lt;/i&gt;&lt;/sup&gt;-Mutated Melanoma
2024cited by 0position: contributordoi
Supplementary Table S2 from A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;&lt;i&gt;V600&lt;/i&gt;&lt;/sup&gt;-Mutated Melanoma
2024cited by 0position: contributordoi
Supplementary Table S3 from A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;&lt;i&gt;V600&lt;/i&gt;&lt;/sup&gt;-Mutated Melanoma
2024cited by 0position: contributordoi
Dabrafenib plus trametinib in BRAFV600E-mutated rare cancers: the phase 2 ROAR trial
Nature Medicine 2023cited by 287position: middledoi
Survival of Patients With Cancer With <i>DPYD</i> Variant Alleles and Dose-Individualized Fluoropyrimidine Therapy—A Matched-Pair Analysis
Journal of Clinical Oncology 2023cited by 52position: middledoi
Dabrafenib plus trametinib in patients with BRAF V600E-mutant anaplastic thyroid cancer: updated analysis from the phase II ROAR basket study
Annals of Oncology 2022cited by 334position: middledoi
Dihydropyrimidine Dehydrogenase Phenotyping Using Pretreatment Uracil: A Note of Caution Based on a Large Prospective Clinical Study
Clinical Pharmacology & Therapeutics 2022cited by 56position: middledoi
A Single-arm Phase II Study Combining NLG207, a Nanoparticle Camptothecin, with Enzalutamide in Advanced Metastatic Castration-resistant Prostate Cancer Post-Enzalutamide
The Oncologist 2022cited by 24position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Jos H. Beijnen · University of Applied Sciences Utrecht125 papers (2012–2024)Alwin D. R. Huitema · University of Applied Sciences Utrecht47 papers (2012–2024)Hilde Rosing · Oncode Institute47 papers (2012–2024)Didier Meulendijks · Utrecht University21 papers (2015–2023)Annemieke Cats · Leiden University Medical Center20 papers (2013–2023)Neeltje Steeghs · Utrecht University19 papers (2014–2024)Bastiaan Nuijen · The Netherlands Cancer Institute17 papers (2012–2024)Dick Pluim · Utrecht University16 papers (2012–2022)Serena Marchetti · Utrecht University14 papers (2012–2021)Linda M. Henricks · Leiden University Medical Center13 papers (2015–2023)Maarten J. Deenen · Utrecht University13 papers (2012–2019)Robin M.J.M. van Geel · Utrecht University11 papers (2012–2020)Élena Elez · Comprehensive Cancer Center Vienna10 papers (2014–2023)Martijn P. Lolkema · Amgen (United States)10 papers (2014–2021)Josep Tabernero · Medical Research Network9 papers (2014–2020) · 9 papers (2012–2019)J. G. Coen van Hasselt · Leiden University9 papers (2012–2018)Ron H.J. Mathijssen · Erasmus University Rotterdam9 papers (2013–2023)Johanna C. Bendell · Roche (Switzerland)8 papers (2014–2020)Rolf W. Sparidans · Utrecht University8 papers (2012–2018)