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Emma Dean

AstraZeneca (Singapore) · US
Area of research
Oncology · Pulmonary and Respiratory Medicine
Research interest
Research interests include PARP inhibition in cancer therapy, Lung Cancer Treatments and Mutations, DNA Repair Mechanisms, and Cancer Genomics and Diagnostics.
h-index
38
citations
5,564
works
287
NIH funding
primary concept
Medicine
email

Recent publications

PRIMAVERA: A Modular Phase I/II Study to Evaluate the Safety, Tolerability, and Efficacy of AZD3470, a Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor, in Participants with Relapsed/Refractory Hematologic Malignancies
Blood 2024cited by 3position: middledoi
Durable responses to ATR inhibition with ceralasertib in tumors with genomic defects and high inflammation
Journal of Clinical Investigation 2023cited by 45position: middledoi
Safety and Preliminary Efficacy of Sabestomig (AZD7789), an Anti-PD-1 and Anti-TIM-3 Bispecific Antibody, in Patients with Relapsed or Refractory Classical Hodgkin Lymphoma Previously Treated with Anti-PD-(L)1 Therapy
Blood 2023cited by 7position: middledoi
Phase 1b study of berzosertib and cisplatin in patients with advanced triple-negative breast cancer
npj Breast Cancer 2022cited by 38position: middledoi
Combination ATR and PARP Inhibitor (CAPRI): A phase 2 study of ceralasertib plus olaparib in patients with recurrent, platinum-resistant epithelial ovarian cancer
Gynecologic Oncology 2021cited by 116position: middledoi
Abstract CT214: ATRiUM: A first-in-human dose escalation phase I trial of ceralasertib (AZD6738) and gemcitabine as combination therapy
Cancer Research 2021cited by 2position: middledoi
Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1–2 trial
The Lancet Oncology 2019cited by 226position: middledoi
AKT Inhibition in Solid Tumors With <i>AKT1</i> Mutations
Journal of Clinical Oncology 2017cited by 324position: middledoi
A Phase I Open-Label Study to Identify a Dosing Regimen of the Pan-AKT Inhibitor AZD5363 for Evaluation in Solid Tumors and in <i>PIK3CA</i> -Mutated Breast and Gynecologic Cancers
Clinical Cancer Research 2017cited by 146position: middledoi
An Adaptive Study to Determine the Optimal Dose of the Tablet Formulation of the PARP Inhibitor Olaparib
Targeted Oncology 2016cited by 131position: middledoi
A phase I, dose escalation, pharmacodynamic, pharmacokinetic, and food-effect study of α2 integrin inhibitor E7820 in patients with advanced solid tumors
Investigational New Drugs 2016cited by 31position: middledoi
Effect of Food on the Pharmacokinetics of Olaparib after Oral Dosing of the Capsule Formulation in Patients with Advanced Solid Tumors
Advances in Therapy 2015cited by 45position: lastdoi
Abstract B109: AZD5363, a catalytic pan-Akt inhibitor, in <i>Akt1</i> E17K mutation positive advanced solid tumors
Molecular Cancer Therapeutics 2015cited by 18position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Ruth Plummer · Sir Bobby Robson Foundation4 papers (2016–2022) · 2 papers (2015–2016)Karin Leunen · KU Leuven2 papers (2015–2016)Hun Ju Lee · The University of Texas MD Anderson Cancer Center2 papers (2023–2024)Elizabeth H. Phillips · Vanderbilt University2 papers (2023–2024)Simon A. Smith · AstraZeneca (Singapore)2 papers (2021–2021)Mark R. Middleton · Oxford MicroMedical (United Kingdom)2 papers (2016–2022)Anitra Fielding · AstraZeneca (United States)2 papers (2015–2016) · 2 papers (2015–2016)Pier Luigi Zinzani · Marche Polytechnic University2 papers (2023–2024) · 1 papers (2023–2023)Craig H. Moskowitz · City of Hope1 papers (2023–2023)Enrico Derenzini · University of Milan1 papers (2024–2024) · 1 papers (2022–2022)P. Bundi · Cambridge University Hospitals NHS Foundation Trust1 papers (2021–2021)Robert Giuntoli · Rockefeller University1 papers (2021–2021)Reshma Rangwala · Karyopharm Therapeutics (United States)1 papers (2019–2019)João Paulo da Silveira Nogueira Lima · AC Camargo Hospital1 papers (2015–2015)Jeffrey Yachnin · Karolinska University Hospital1 papers (2019–2019)José Baselga · Vall d'Hebron Institute of Oncology1 papers (2015–2015)