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Wai‐Man Chan

Broad Institute ·
Area of research
Ophthalmology · Pathology and Forensic Medicine
Research interest
Research interests include Retinal Diseases and Treatments, Ocular Diseases and Behçet’s Syndrome, Ophthalmology and Eye Disorders, and Glaucoma and retinal disorders.
h-index
53
citations
10,466
works
222
NIH funding
primary concept
email

Recent publications

Systematic phenotype and genotype characterization of Moebius syndrome
Genetics in Medicine Open 2025cited by 1position: middledoi
Expanding the genetics and phenotypes of ocular congenital cranial dysinnervation disorders
Genetics in Medicine 2024cited by 16position: middledoi
Presence of Copy Number Variants Associated With Esotropia in Patients With Exotropia
JAMA Ophthalmology 2024cited by 10position: middledoi
A cell type-aware framework for nominating non-coding variants in Mendelian regulatory disorders
Nature Communications 2024cited by 9position: middledoi
A recurrent missense variant in the E3 ubiquitin ligase substrate recognition subunit FEM1B causes a rare syndromic neurodevelopmental disorder
Genetics in Medicine 2024cited by 6position: middledoi
Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis
Nature Genetics 2023cited by 34position: middledoi
Recessive variants in <i>COL25A1</i> gene as novel cause of arthrogryposis multiplex congenita with ocular congenital cranial dysinnervation disorder
Human Mutation 2022cited by 21position: middledoi
Novel variants in TUBA1A cause congenital fibrosis of the extraocular muscles with or without malformations of cortical brain development
European Journal of Human Genetics 2021cited by 30position: middledoi
TUBB3 Arg262His causes a recognizable syndrome including CFEOM3, facial palsy, joint contractures, and early-onset peripheral neuropathy
Human Genetics 2021cited by 29position: middledoi
Optic Nerve Head and Retinal Abnormalities Associated with Congenital Fibrosis of the Extraocular Muscles
International Journal of Molecular Sciences 2021cited by 12position: middledoi
Recurrent Rare Copy Number Variants Increase Risk for Esotropia
Investigative Ophthalmology & Visual Science 2020cited by 19position: middledoi
Decreased ACKR3 (CXCR7) function causes oculomotor synkinesis in mice and humans
Human Molecular Genetics 2019cited by 18position: middledoi
Congenital monocular elevation deficiency associated with a novel<i>TUBB3</i>gene variant
British Journal of Ophthalmology 2019cited by 17position: middledoi
Genome-Wide Association Study Identifies a Susceptibility Locus for Comitant Esotropia and Suggests a Parent-of-Origin Effect
Investigative Ophthalmology & Visual Science 2018cited by 41position: middledoi
Altered White Matter Organization in the TUBB3 E410K Syndrome
Cerebral Cortex 2018cited by 22position: middledoi
Recessive MYF5 Mutations Cause External Ophthalmoplegia, Rib, and Vertebral Anomalies
The American Journal of Human Genetics 2018cited by 16position: middledoi
A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome
Nature Communications 2017cited by 107position: middledoi
Biallelic mutations in human DCC cause developmental split-brain syndrome
Nature Genetics 2017cited by 79position: middledoi
Human Schwann cells exhibit long‐term cell survival, are not tumorigenic and promote repair when transplanted into the contused spinal cord
Glia 2017cited by 49position: middledoi
Mutant α2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome
Journal of Clinical Investigation 2017cited by 35position: middledoi
Loss of MAFB Function in Humans and Mice Causes Duane Syndrome, Aberrant Extraocular Muscle Innervation, and Inner-Ear Defects
The American Journal of Human Genetics 2016cited by 92position: middledoi
Two unique <i>TUBB3</i> mutations cause both CFEOM3 and malformations of cortical development
American Journal of Medical Genetics Part A 2015cited by 76position: middledoi
Expanding the Phenotypic Spectrum and Variability of Endocrine Abnormalities Associated With TUBB3 E410K Syndrome
The Journal of Clinical Endocrinology & Metabolism 2015cited by 26position: middledoi
Transforming cardiac rehabilitation into broad-based healthy lifestyle programs to combat noncommunicable disease
Expert Review of Cardiovascular Therapy 2015cited by 23position: middledoi
Human CFEOM1 Mutations Attenuate KIF21A Autoinhibition and Cause Oculomotor Axon Stalling
Neuron 2014cited by 123position: middledoi
Diagnostic Distinctions and Genetic Analysis of Patients Diagnosed with Moebius Syndrome
Ophthalmology 2014cited by 93position: middledoi
A novel syndrome caused by the E410K amino acid substitution in the neuronal β-tubulin isotype 3
Brain 2013cited by 129position: middledoi
Autosomal-dominant nystagmus, foveal hypoplasia and presenile cataract associated with a novel PAX6 mutation
European Journal of Human Genetics 2013cited by 58position: middledoi
Effect of Gender on Recovery After Spinal Cord Injury
Translational Stroke Research 2013cited by 55position: firstdoi
<i>RYR1</i>Mutations as a Cause of Ophthalmoplegia, Facial Weakness, and Malignant Hyperthermia
JAMA Ophthalmology 2013cited by 35position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Elizabeth C. Engle · Boston Children's Hospital23 papers (2012–2024)Caroline Andrews · National Institutes of Health11 papers (2012–2018)David G. Hunter · University of Colorado Boulder10 papers (2012–2024) · 9 papers (2012–2024) · 6 papers (2015–2024)Irène Gottlob · University of Leicester6 papers (2013–2021)Sherin Shaaban · University of Utah6 papers (2012–2021)Gail Maconachie · University of Leicester5 papers (2016–2021)Silvio Alessandro Di Gioia · University of Lausanne5 papers (2016–2022)Caroline D. Robson · Boston Children's Hospital5 papers (2012–2021)P. Ellen Grant · Harvard University4 papers (2012–2018)Sheena Chew · Biogen (United States)4 papers (2012–2018)Alicia Nugent · Gene Therapy Laboratory3 papers (2014–2017)Max A. Tischfield · Rutgers, The State University of New Jersey3 papers (2012–2016)Brenda Barry · Boston Children's Hospital3 papers (2019–2024) · 3 papers (2018–2022)Darren T. Oystreck · Dalhousie University3 papers (2012–2014)Damien D. Pearse · University of Miami3 papers (2012–2017)Mervyn G. Thomas · University of Leicester3 papers (2013–2021)Brenda J. Barry · Boston Children's Hospital3 papers (2019–2022)