Area of research
Immunology · Molecular Biology
Research interest
We are broadly interested in mechanisms of signal transduction, namely how a cell communicates with its surroundings and within itself. In particular, we are fascinated by how a cell detects harmful or foreign insults and mounts an appropriate response to restore homeostasis.
PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling
Innate immune sensing via the cGAS-STING pathway restricts extrachromosomal DNA–driven tumorigenesis
From NF-κB to cGAS: An interview with Prof. Zhijian James Chen on unraveling innate immunity
The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion
cGAS goes viral: A conserved immune defense system from bacteria to humans
cGAS-activated endothelial cell–T cell cross-talk initiates tertiary lymphoid structure formation
Discovery of cGAS as a DNA-Sensing Enzyme That Triggers Inflammation
Ubiquitin-like conjugation by bacterial cGAS enhances anti-phage defence
Vaccinia E5 is a major inhibitor of the DNA sensor cGAS
Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB
Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer
An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif
Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression
Phosphorylation and chromatin tethering prevent cGAS activation during mitosis
TBK1 recruitment to STING mediates autoinflammatory arthritis caused by defective DNA clearance
Cooperative DNA binding mediated by KicGAS/ORF52 oligomerization allows inhibition of DNA-induced phase separation and activation of cGAS
Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway
MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway
Old dogs, new trick: classic cancer therapies activate cGAS
STEEP mediates STING ER exit and activation of signaling
cGAS suppresses genomic instability as a decelerator of replication forks
Type I Interferon Response in Radiation-Induced Anti-Tumor Immunity
Author Correction: STEEP mediates STING ER exit and activation of signaling
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway
cGAS in action: Expanding roles in immunity and inflammation
Roles of the cGAS-STING Pathway in Cancer Immunosurveillance and Immunotherapy
Discovery of Small-Molecule Cyclic GMP-AMP Synthase Inhibitors
The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer
DNA-induced liquid phase condensation of cGAS activates innate immune signaling
Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids