ILC3s regulate the gut microbiota via host intestinal galactosylation to limit pathogen infection in mice
ILC3s promote intestinal tuft cell hyperplasia and anthelmintic immunity through RANK signaling
Multi-omics integration reveals functional signatures of gut microbiome in atherosclerosis
Lymphotoxin-β promotes breast cancer bone metastasis colonization and osteolytic outgrowth
Targeting the Dendritic Cell-Secreted Immunoregulatory Cytokine CCL22 Alleviates Radioresistance
1.Tumbath S, Jiang L, Li X, Zhang T, Zahid KR, Zhao Y, Zhou H, Yin Z, Lu T, Jiang S, Chen Y, Chen X, Fu YX*, Huang X. β-Lapachone promotes the recruitment and polarization of tumor-associated neutrophils (TANs) toward an antitumor (N1) phenotype in NQO1-positive cancers. Oncoimmunology. 2024 Jun 4;1
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2.Zou Z, Shen J, Xue D, Li H, Xu L, Cao W, Wang W, Fu YX*, Peng H. Anti-PD-1 cis-delivery of low-affinity IL-12 activates intratumoral CD8+T cells for systemic antitumor responses. Nat Commun. 2024 Jun 3;15(1):4701.
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3.Bugno J, Wang L, Yu X, Cao X, Wang J, Huang X, Yang K, Piffko A, Chen K, Luo SY, Naccasha E, Hou Y, Fu S, He C, Fu YX, Liang HL, Weichselbaum RR. Targeting the dendritic cell-secreted immunoregulatory cytokine CCL22 alleviates radioresistance. Clin Cancer Res. 2024
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4.Wang W, Fu YX*. Promises and challenges of organoids: From humanized to human derived.Cell Stem Cell. 2024 Mar 7;31(3):281-282.
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5.Huang J, Zhang X, Xu H, Fu L, Liu Y, Zhao J, Huang J, Song Z, Zhu M, Fu YX, Chen YG, Guo X. Intraepithelial Lymphocytes Promote Intestinal Regeneration through CD160/HVEM Signaling. Mucosal Immunol. 2024 Feb 8:S1933-0219(24)00008-4.
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7.Wang J, Li S, Wang M, Wang X, Chen S, Sun Z, Ren X, Huang G, Sumer BD, Yan N, Fu YX, Gao J. STING licensing of type I dendritic cells potentiates antitumor immunity. Sci Immunol. 2024 Feb 16;9(92):eadj3945.
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6.Liu G, Ma N, Cheng K, Feng Q, Ma X, Yue Y, Li Y, Zhang T, Gao X, Liang J, Zhang L, Wang X, Ren Z, Fu YX, Zhao X, Nie G. Bacteria-derived nanovesicles enhance tumour vaccination by trained immunity. Nat Nanotechnol. 2023 Dec 5
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8.Huang Y, Lu C, Wang H, Gu L, Fu YX*, Li GM. DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability. Nat Commun. 2023 Aug 28;14(1):5246
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10.Huang Y, Lu C, Wang H, Gu L, Fu YX*, Li GM. DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability. Nat Commun. 2023 Aug 28;14(1):5246.
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11.Wang X, Liu L, Yue T, Sun Z, Bae J, Tseng KF, Zhang A, Qiao J, Fu YX*. Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates dysfunctional CD8+ T cells. Signal Transduct Target Ther. 2023 Jul 12;8(1):268.
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12.Zhang Y, Song Q, Cassady K, Lee M, Tang H, Zheng M, Wang B, Schones DE, Fu YX*, Riggs AD, Martin PJ, Feng R, Zeng D. Share. Blockade of trans PD-L1 interaction with CD80 augments antitumor immunity. Proc Natl Acad Sci U S A. 2023， 120(16):e2205085120
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13.Zhang Y, Song Q, Cassady K, Lee M, Tang H, Zheng M, Wang B, Schones DE, Fu YX*, Riggs AD, Martin PJ, Feng R, Zeng D. Share. Blockade of trans PD-L1 interaction with CD80 augments antitumor immunity. Proc Natl Acad Sci U S A. 2023， 120(16):e2205085120
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15.Peng H, Fu YX*. Towards developing a variant-proof SARS-CoV-2 vaccine. Cell Res. 2023. 33(1):5-6
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16.Meng CY, Sun S, Liang Y, Xu H, Zhang C, Zhang M, Wang FS, Fu YX*, Peng H. Engineered anti-PDL1 with IFNα targets both immunoinhibitory and activating signals in the liver to break HBV immune tolerance. Gut. 2023. 72(8):1544-1554，
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Zinc cyclic di-AMP nanoparticles target and suppress tumours via endothelial STING activation and tumour-associated macrophage reinvigoration
A tumor-specific pro-IL-12 activates preexisting cytotoxic T cells to control established tumors
Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer
14.He Q, Sun S, Chen X, Hu Z, Zhang Y, Peng H, Fu YX*, Yang J, Chen L. The Bivalent COVID-19 Booster Immunization after Three Doses of Inactivated Vaccine Augments the Neutralizing Antibody Response against Circulating Omicron Sublineages J Clin Med. 2022 Dec 24;12(1):146
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17.Bae J, Liu L, Moore C, Hsu E, Zhang A, Ren Z, Sun Z, Wang X, Zhu J, Shen J, Qiao J, Fu YX*. IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8+ T cells to overcome immunotherapy resistance in cancer. Nat Cell Biol. 2022 24(12):1754-1765.
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18.He Q, Sun S, Chen X, Hu Z, Zhang Y, Peng H, Fu YX, Yang J, Chen L. The Bivalent COVID-19 Booster Immunization after Three Doses of Inactivated Vaccine Augments the Neutralizing Antibody Response against Circulating Omicron Sublineages. J Clin Med. 2022 Dec 24;12(1):146.
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19.Shen J, Zou Z, Guo J, Cai Y, Xue D, Liang Y, Wang W, Peng H, Fu YX*. An engineered concealed IL-15-R elicits tumor-specific CD8+T cell responses through PD-1-cis delivery. J Exp Med. 2022 Dec 5;219(12): e20220745.
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20.Yang K, Han W, Jiang X, Piffko A, Bugno J, Han C, Li S, Liang H, Xu Z, Zheng W, Wang L, Wang J, Huang X, Ting JPY, Fu YX, Lin W, Weichselbaum RR. Zinc cyclic di-AMP nanoparticles target and suppress tumours via endothelial STING activation and tumour-associated macrophage reinvigoration. Nat Nano
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21.Moore C, Bae J, Liu L, Li H, Fu YX*, Qiao J. Exogenous signaling repairs defective T cell signaling inside the tumor microenvironment for better immunity. JCI Insight. 2022 Sep 8;7(17):e159479
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22.Feng Q, Liu Z, Yu X, Huang T, Chen J, Wang J, Wilhelm J, Li S, Song J, Li W, Sun Z, Sumer BD, Li B, Fu YX*, Gao J. Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity. Nat Commun. 2022 Sep 6;13(1):4981.
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23.Zhang Z, He Q, Zhao W, Li Y, Yang J, Hu Z, Chen X, Peng H, Fu YX, Chen L, Lu L. A Heterologous V-01 or Variant-Matched Bivalent V-01D-351 Booster following Primary Series of Inactivated Vaccine Enhances the Neutralizing Capacity against SARS-CoV-2 Delta and Omicron Strains. J Clin Med. 2022 Jul 1
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