Area of research
Physiology · Cancer Research
Research interest
Research interests include Nitric Oxide and Endothelin Effects, Cancer, Hypoxia, and Metabolism, Colorectal Cancer Treatments and Studies, and Eicosanoids and Hypertension Pharmacology.
The Space Omics and Medical Atlas (SOMA) and international astronaut biobank
Biomolecular condensates create phospholipid-enriched microenvironments
Excess folic acid intake increases DNA de novo point mutations
LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma
Distinct cAMP Signaling Microdomains Differentially Regulate Melanosomal pH and Pigmentation
Exogenous and Endogenous Sources of Serine Contribute to Colon Cancer Metabolism, Growth, and Resistance to 5-Fluorouracil
A retinoic acid receptor β2 agonist attenuates transcriptome and metabolome changes underlying nonalcohol-associated fatty liver disease
CD73 Blockade Promotes Dendritic Cell Infiltration of Irradiated Tumors and Tumor Rejection
APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice
High-fructose corn syrup enhances intestinal tumor growth in mice
FTO controls reversible m6Am RNA methylation during snRNA biogenesis
Antibody cross-reactivity accounts for widespread appearance of m1A in 5’UTRs
Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations
Accelerated lipid catabolism and autophagy are cancer survival mechanisms under inhibited glutaminolysis
HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons
Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology
Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure
Fibroblast bioenergetics to classify amyotrophic lateral sclerosis patients
Reversible methylation of m6Am in the 5′ cap controls mRNA stability
Metabolomics enables precision medicine: “A White Paper, Community Perspective”
Role of RPL39 in Metaplastic Breast Cancer
Vitamin C selectively kills <i>KRAS</i> and <i>BRAF</i> mutant colorectal cancer cells by targeting GAPDH
Inhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer
Serum Metabolite Biomarkers Discriminate Healthy Smokers from COPD Smokers
Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling
KCNQ1, KCNE2, and Na <sup>+</sup> -Coupled Solute Transporters Form Reciprocally Regulating Complexes That Affect Neuronal Excitability