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Joseph L. Watson

University of Washington · US
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Area of research
Molecular Biology · Radiology, Nuclear Medicine and Imaging · protein folding alphafold
Research interest
Research interests include Protein Structure and Dynamics, RNA and protein synthesis mechanisms, Monoclonal and Polyclonal Antibodies Research, and Machine Learning in Bioinformatics.
h-index
21
citations
4,060
works
63
NIH funding
primary concept
Biology
email

Recent publications

Improved protein binder design using β-pairing targeted RFdiffusion
Nature Communications 2026cited by 2position: middledoi
Atomically accurate de novo design of antibodies with RFdiffusion
Nature 2025cited by 50position: middledoi
Diffusing protein binders to intrinsically disordered proteins
Nature 2025cited by 36position: middledoi
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
Nature Communications 2025cited by 13position: middledoi
Bottom-up design of Ca2+ channels from defined selectivity filter geometry
Nature 2025cited by 2position: middledoi
De novo design of pH-responsive self-assembling helical protein filaments
Nature Nanotechnology 2024cited by 61position: middledoi
De novo design of protein structure and function with RFdiffusion
Nature 2023cited by 1,843position: firstdoi
De novo design of high-affinity binders of bioactive helical peptides
Nature 2023cited by 217position: middledoi
Macromolecular condensation buffers intracellular water potential
Nature 2023cited by 166position: firstdoi
Zero‐shot mutation effect prediction on protein stability and function using <scp>RoseTTAFold</scp>
Protein Science 2023cited by 36position: middledoi
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells
Cell 2023cited by 31position: firstdoi
Scaffolding protein functional sites using deep learning
Science 2022cited by 462position: middledoi
Design of biologically active binary protein 2D materials
Nature 2021cited by 143position: middledoi
Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology
Nature Communications 2021cited by 62position: middledoi
Author Correction: Design of biologically active binary protein 2D materials
Nature 2021cited by 4position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

David Baker · Howard Hughes Medical Institute7 papers (2021–2025)Emmanuel Derivery · MRC Laboratory of Molecular Biology5 papers (2021–2024) · 3 papers (2021–2023)Justin M. Kollman · Seattle University3 papers (2021–2024)Justin Decarreau · University of Washington3 papers (2021–2024)William Sheffler · University of Washington3 papers (2021–2024) · 3 papers (2021–2023)James J. De Yoreo · Pacific Northwest National Laboratory3 papers (2021–2024)Clemens F. Kaminski · Cancer Research UK Cambridge Center2 papers (2021–2021)Fang Jiao · Institute of Hydrobiology2 papers (2021–2021)Hannele Ruohola‐Baker · California Institute for Regenerative Medicine2 papers (2021–2021)Matthew C. Johnson · University of California, San Francisco2 papers (2021–2021) · 2 papers (2021–2021) · 2 papers (2021–2021) · 2 papers (2021–2021)Greg L. Hura · Lawrence Berkeley National Laboratory2 papers (2021–2021)Minkyung Baek · Seoul National University of Science and Technology2 papers (2022–2023) · 2 papers (2021–2021) · 2 papers (2021–2021)David Juergens · University of Washington2 papers (2022–2023)
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