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William Sheffler

University of Washington · US
Area of research
Molecular Biology · Ecology
Research interest
Research interests include Protein Structure and Dynamics, Bacteriophages and microbial interactions, Enzyme Structure and Function, and Monoclonal and Polyclonal Antibodies Research.
h-index
36
citations
11,812
works
88
NIH funding
primary concept
Computer science
email

Recent publications

Bond-centric modular design of protein assemblies
Nature Materials 2025cited by 14position: middledoi
De novo design of pH-responsive self-assembling helical protein filaments
Nature Nanotechnology 2024cited by 61position: middledoi
Computational design of non-porous pH-responsive antibody nanoparticles
Nature Structural & Molecular Biology 2024cited by 30position: middledoi
De novo design of protein structure and function with RFdiffusion
Nature 2023cited by 1,843position: middledoi
De novo design of modular peptide-binding proteins by superhelical matching
Nature 2023cited by 79position: middledoi
Fast and versatile sequence-independent protein docking for nanomaterials design using RPXDock
PLoS Computational Biology 2023cited by 36position: firstdoi
Design of protein-binding proteins from the target structure alone
Nature 2022cited by 554position: middledoi
Computational design of mechanically coupled axle-rotor protein assemblies
Science 2022cited by 54position: middledoi
Exploration of Structured Symmetric Cyclic Peptides as Ligands for Metal-Organic Frameworks
Chemistry of Materials 2022cited by 13position: middledoi
Designed proteins assemble antibodies into modular nanocages
Science 2021cited by 181position: middledoi
Design of biologically active binary protein 2D materials
Nature 2021cited by 143position: middledoi
Design of multi-scale protein complexes by hierarchical building block fusion
Nature Communications 2021cited by 88position: middledoi
Author Correction: Design of biologically active binary protein 2D materials
Nature 2021cited by 4position: middledoi
Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens
eLife 2020cited by 186position: middledoi
Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus
Cell 2019cited by 482position: middledoi
Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle
Nature Communications 2019cited by 212position: middledoi
Multi-input chemical control of protein dimerization for programming graded cellular responses
Nature Biotechnology 2019cited by 86position: middledoi
De novo design of a fluorescence-activating β-barrel
Nature 2018cited by 374position: middledoi
Accurate computational design of multipass transmembrane proteins
Science 2018cited by 202position: middledoi
Efficient flexible backbone protein–protein docking for challenging targets
Bioinformatics 2018cited by 189position: middledoi
De novo design of self-assembling helical protein filaments
Science 2018cited by 154position: middledoi
Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site
Nature Biotechnology 2017cited by 132position: middledoi
Accurate design of megadalton-scale two-component icosahedral protein complexes
Science 2016cited by 607position: middledoi
Design of a hyperstable 60-subunit protein icosahedron
Nature 2016cited by 478position: middledoi
Computational design of self-assembling cyclic protein homo-oligomers
Nature Chemistry 2016cited by 158position: middledoi
Computational design of a homotrimeric metalloprotein with a trisbipyridyl core
Proceedings of the National Academy of Sciences 2016cited by 56position: middledoi
Accurate design of co-assembling multi-component protein nanomaterials
Nature 2014cited by 579position: middledoi
Computational Design of Self-Assembling Protein Nanomaterials with Atomic Level Accuracy
Science 2012cited by 673position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

David Baker · Howard Hughes Medical Institute23 papers (2012–2025)Neil P. King · University of Washington9 papers (2012–2024)Jorge A. Fallas · Seattle University5 papers (2016–2024)Yang Hsia · Lawrence Berkeley National Laboratory5 papers (2016–2025)Justin M. Kollman · Seattle University5 papers (2018–2024)Justin Decarreau · University of Washington5 papers (2018–2024)George Ueda · Seattle University5 papers (2016–2024)Tamir Gonen · Howard Hughes Medical Institute4 papers (2012–2016)David Veesler · Howard Hughes Medical Institute4 papers (2019–2022)James J. De Yoreo · Pacific Northwest National Laboratory4 papers (2018–2024)Emmanuel Derivery · MRC Laboratory of Molecular Biology4 papers (2021–2024)TJ Brunette · Align Technology (United States)4 papers (2016–2023)Lance Stewart · Joint Center for Structural Genomics4 papers (2018–2023)Banumathi Sankaran · Lawrence Berkeley National Laboratory4 papers (2016–2020)Peter H. Zwart · Lawrence Berkeley National Laboratory3 papers (2016–2020)Rachel L. Redler · New York University3 papers (2021–2025)Una Nattermann · Lawrence Berkeley National Laboratory3 papers (2016–2022)Jiajun Chen · Fudan University3 papers (2018–2021)Joseph L. Watson · University of Washington3 papers (2021–2024) · 3 papers (2014–2016)