Area of research
Infectious Diseases · Animal Science and Zoology
Research interest
Research interests include SARS-CoV-2 and COVID-19 Research, Animal Virus Infections Studies, Bacteriophages and microbial interactions, and Monoclonal and Polyclonal Antibodies Research.
Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses
Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses
Functional and antigenic landscape of the Nipah virus receptor-binding protein
Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics
Local structural flexibility drives oligomorphism in computationally designed protein assemblies
Computationally designed mRNA-launched protein nanoparticle immunogens elicit protective antibody and T cell responses in mice
Designed miniproteins potently inhibit and protect against MERS-CoV
SARS-CoV-2 nsp1 mediates broad inhibition of translation in mammals
HKU25 clade MERS-related coronaviruses use ACE2 as a functional receptor
Potent neutralization of Marburg virus by a vaccine-elicited antibody
Spike deep mutational scanning helps predict success of SARS-CoV-2 clades
Persistent immune imprinting occurs after vaccination with the COVID-19 XBB.1.5 mRNA booster in humans
A potent pan-sarbecovirus neutralizing antibody resilient to epitope diversification
Human coronavirus HKU1 recognition of the TMPRSS2 host receptor
Hierarchical design of pseudosymmetric protein nanocages
Therapeutic administration of a cross-reactive mAb targeting the fusion glycoprotein of Nipah virus protects nonhuman primates
Mapping immunodominant sites on the MERS-CoV spike glycoprotein targeted by infection-elicited antibodies in humans
Streptomyces umbrella toxin particles block hyphal growth of competing species
A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines
Design of customized coronavirus receptors
Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features
Potent neutralization of SARS-CoV-2 variants by RBD nanoparticle and prefusion-stabilized spike immunogens
Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV
Isolation and escape mapping of broadly neutralizing antibodies against emerging delta-coronaviruses
Neutralization, effector function and immune imprinting of Omicron variants
Broadly neutralizing antibodies against sarbecoviruses generated by immunization of macaques with an AS03-adjuvanted COVID-19 vaccine
Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus
Antigen spacing on protein nanoparticles influences antibody responses to vaccination
Structural changes in the SARS-CoV-2 spike E406W mutant escaping a clinical monoclonal antibody cocktail
Automatic and accurate ligand structure determination guided by cryo-electron microscopy maps