Area of research
Molecular Biology · Cancer Research
Research interest
Research interests include Fibroblast Growth Factor Research, Protein Degradation and Inhibitors, CRISPR and Genetic Engineering, and Cancer Genomics and Diagnostics.
Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants
Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma
Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors
Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages
BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma
PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation
Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state
TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma
Acquired FGFR and FGF Alterations Confer Resistance to Estrogen Receptor (ER) Targeted Therapy in ER+ Metastatic Breast Cancer
Genome-wide CRISPR and small-molecule screens uncover targetable dependencies in ATRT
LGG-35. FUNCTIONAL GENOMIC APPROACHES TO IDENTIFY THERAPEUTIC TARGETS IN <i>MYB</i> AND <i>MYBL1</i> EXPRESSING PEDIATRIC LOW-GRADE GLIOMAS
A dominant-negative effect drives selection of <i>TP53</i> missense mutations in myeloid malignancies
Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies
A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma
Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia
Mutational processes shape the landscape of TP53 mutations in human cancer
Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling
Regulation of Cellular Heterogeneity and Rates of Symmetric and Asymmetric Divisions in Triple-Negative Breast Cancer
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles
Synergistic interactions with PI3K inhibition that induce apoptosis
High-throughput Phenotyping of Lung Cancer Somatic Mutations
Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles
Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers
KRAS and YAP1 Converge to Regulate EMT and Tumor Survival
An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia
A melanocyte lineage program confers resistance to MAP kinase pathway inhibition