Area of research
Molecular Biology · Hematology
Research interest
Research interests include Acute Myeloid Leukemia Research, Protein Degradation and Inhibitors, Epigenetics and DNA Methylation, and Acute Lymphoblastic Leukemia research.
Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions
Catalytic Inhibition of KAT6/KAT7 Enhances the Efficacy and Overcomes Primary and Acquired Resistance to Menin Inhibitors in MLL Leukemia
KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i> -Rearranged Acute Myeloid Leukemia
Combined inhibition of KAT6A/B and Menin reverses estrogen receptor-driven gene expression programs in breast cancer
p300/CBP is an essential driver of pathogenic enhancer activity and gene expression in Ewing sarcoma
The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wild-Type p53 to Exert the Dominant-Negative Effect
PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway
Inherited blood cancer predisposition through altered transcription elongation
The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia
MEN1 mutations mediate clinical resistance to menin inhibition
Epitope editing enables targeted immunotherapy of acute myeloid leukaemia
Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of <i>KMT2A</i>-r and <i>NPM1c</i> AML
MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer
Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia
Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia
Antigen presentation safeguards the integrity of the hematopoietic stem cell pool
IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia
Epitope Engineered Hematopoietic Stem and Progenitor Cells to Enable CAR-T Cell Immunotherapy for Acute Myeloid Leukemia
The menin-MLL1 interaction is a molecular dependency in <i>NUP98</i>-rearranged AML
Therapeutic targeting of preleukemia cells in a mouse model of <i>NPM1</i> mutant acute myeloid leukemia
Synergistic targeting of <i>FLT3</i> mutations in AML via combined menin-MLL and FLT3 inhibition
Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition
Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development
A dominant-negative effect drives selection of <i>TP53</i> missense mutations in myeloid malignancies
Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia
Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma
A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response
Peptidomimetic blockade of MYB in acute myeloid leukemia
MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia
Author response: Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma
Coarse-graining, Renormalization, and Fractal Homogenization
Renormalization in Statistical Mechanics and Partial Differential Equations
Quantitative Stochastic Homogenization and Renormalization Methods
Quantitative Methods for Modeling Properties of Random Media
PostDoctoral Research Fellowship