Area of research
Molecular Biology · Hematology
Research interest
Research interests include Acute Myeloid Leukemia Research, Epigenetics and DNA Methylation, Myeloproliferative Neoplasms: Diagnosis and Treatment, and Protein Degradation and Inhibitors.
Mechanical confinement governs phenotypic plasticity in melanoma
A nucleosome switch primes hepatitis B virus infection
Epigenetic mechanisms controlling human leukemia stem cells and therapy resistance
A High-Fiber, Plant-Based Diet in Myeloma Precursor Disorders: Results from the NUTRIVENTION Clinical Trial and Preclinical Vk*MYC Model
Extrachromosomal DNA micronucleation constrains tumour fitness and improves patient survival
SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence
Extracellular matrix regulates lineage plasticity in prostate cancer through YAP/TEAD
An epigenetic barrier sets the timing of human neuronal maturation
Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis
SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing
CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation
Intercellular extrachromosomal DNA copy-number heterogeneity drives neuroblastoma cell state diversity
Passenger Gene Coamplifications Create Collateral Therapeutic Vulnerabilities in Cancer
Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer
Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis
Epigenetic dysregulation from chromosomal transit in micronuclei
Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells
A reversible epigenetic memory of inflammatory injury controls lineage plasticity and tumor initiation in the mouse pancreas
Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers
Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1
GABA Regulates Electrical Activity and Tumor Initiation in Melanoma
KMT2D suppresses Sonic hedgehog-driven medulloblastoma progression and metastasis
MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer
Mutational topography reflects clinical neuroblastoma heterogeneity
Intercellular extrachromosomal DNA copy number heterogeneity drives cancer cell state diversity
Anatomic position determines oncogenic specificity in melanoma
CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction
BMP2/SMAD pathway activation in JAK2/p53-mutant megakaryocyte/erythroid progenitors promotes leukemic transformation
Epigenetic plasticity cooperates with emergent cell-cell interactions to drive neoplastic tissue remodeling in the pancreas
Amplicon structure creates collateral therapeutic vulnerability in cancer