Area of research
Oncology · Immunology
Research interest
Research interests include Cancer Genomics and Diagnostics, Pancreatic and Hepatic Oncology Research, Immune cells in cancer, and Cancer Immunotherapy and Biomarkers.
A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy
Oncogenic and tumor-suppressive forces converge on a progenitor niche at the benign-to-malignant transition
α-Ketoglutarate dehydrogenase is a therapeutic vulnerability in acute myeloid leukemia
A RAS(ON) Multi-Selective Inhibitor Combination Therapy Triggers Long-term Tumor Control through Senescence-Associated Tumor-Immune Equilibrium in Pancreatic Ductal Adenocarcinoma
SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence
Stromal KITL/SCF Maintains Pancreas Tissue Homeostasis and Restrains Tumor Progression
Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction
Interferon Epsilon Loss Is Elusive 9p21 Link to Immune-Cold Tumors, Resistant to Immune Checkpoint Therapy, and Endogenous CXCL9/10 Induction
Author Correction: Senolytic CAR T cells reverse senescence-associated pathologies
Timing of treatment shapes the path to androgen receptor signaling inhibitor resistance in prostate cancer
Timing of treatment shapes the path to androgen receptor signaling inhibitor resistance in prostate cancer
STING inhibits the reactivation of dormant metastasis in lung adenocarcinoma
Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis
EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance
MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer
Ordered and deterministic cancer genome evolution after p53 loss
Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity
Genomic and transcriptomic determinants of response to neoadjuvant therapy in rectal cancer
Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants
MACHETE identifies interferon-encompassing chromosome 9p21.3 deletions as mediators of immune evasion and metastasis
Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer
Increased p53 expression induced by APR-246 reprograms tumor-associated macrophages to augment immune checkpoint blockade
A preclinical platform for assessing antitumor effects and systemic toxicities of cancer drug targets
Epigenetic plasticity cooperates with emergent cell-cell interactions to drive neoplastic tissue remodeling in the pancreas
Ogdh Is a Genetic Vulnerability and Therapeutic Target in Acute Myeloid Leukemia
A gene–environment-induced epigenetic program initiates tumorigenesis
Senolytic CAR T cells reverse senescence-associated pathologies
Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer
A unifying paradigm for transcriptional heterogeneity and squamous features in pancreatic ductal adenocarcinoma
Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer