Area of research
Oncology · Molecular Biology
Research interest
Research focused on Cancer research and Adenocarcinoma, with related work in Computational biology, Chromatin, Blockade. Notable publications include 'WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC', 'Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation', and 'HiC-DC+ enables systematic 3D interaction calls and differential analysis for Hi-C and HiChIP'.
Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis
ATR inhibition activates cancer cell cGAS/STING-interferon signaling and promotes antitumor immunity in small-cell lung cancer
SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing
CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation
ChromaFold predicts the 3D contact map from single-cell chromatin accessibility
Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers
WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC
Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation
HiC-DC+ enables systematic 3D interaction calls and differential analysis for Hi-C and HiChIP
Intrinsically Disordered Proteins: Controlled Chaos or Random Walk
The cis conformation of proline leads to weaker binding of a p53 peptide to MDM2 compared to trans
The Effect of Proline CIS Trans Isomerization on P53 MDM2 Binding
Impact of the K24N mutation on the transactivation domain of p53 and its binding to murine double-minute clone 2
The effects of nanoscale geometry and spillover on room temperature storage of hydrogen on silica nanosprings
Absolute Binding Affinity Calculation for MDM2 Bound to a Disordered Fragment of P53
Impact of K24N Mutation on p53TAD and its Interaction with MDM2