Area of research
Molecular Biology · Cell Biology
Research interest
Research interests include Protein Kinase Regulation and GTPase Signaling, Cellular transport and secretion, Phosphodiesterase function and regulation, and Receptor Mechanisms and Signaling.
mTORC1 restricts TFE3 activity by auto-regulating its presence on lysosomes
Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling
Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns
mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy
Treatment of ARS deficiencies with specific amino acids
NAA80 bi-allelic missense variants result in high-frequency hearing loss, muscle weakness and developmental delay
De Novo Heterozygous POLR2A Variants Cause a Neurodevelopmental Syndrome with Profound Infantile-Onset Hypotonia
Identification of a Loss-of-Function Mutation in the Context of Glutaminase Deficiency and Neonatal Epileptic Encephalopathy
GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay
Efficient Intracellular Delivery of Native Proteins
Structure-Guided Design of Selective Epac1 and Epac2 Agonists
Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes
cNMP-AMs mimic and dissect bacterial nucleotidyl cyclase toxin effects
Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases
Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling