Area of research
Hematology · Molecular Biology
Research interest
Research interests include Acute Myeloid Leukemia Research, Protein Degradation and Inhibitors, Hematopoietic Stem Cell Transplantation, and Acute Lymphoblastic Leukemia research.
ALKBH1 Drives Tumorigenesis and Drug Resistance via tRNA-decoding Reprogramming and Codon-biased Translation
DDX6 undergoes phase separation to modulate metabolic plasticity and chemoresistance
YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies
METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal
The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia
Epigenetic regulator genes direct lineage switching in <i>MLL/AF4</i> leukemia
Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion
Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling
METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification
Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia
Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia
The full transforming capacity of MLL-Af4 is interlinked with lymphoid lineage commitment
Instructive Role of MLL-Fusion Proteins Revealed by a Model of t(4;11) Pro-B Acute Lymphoblastic Leukemia
The AS‐RBM15 lncRNA enhances RBM15 protein translation during megakaryocyte differentiation
MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199
Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia
UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO
Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal
<i>TET1</i> plays an essential oncogenic role in <i>MLL</i> -rearranged leukemia
PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells
miR-9 is an essential oncogenic microRNA specifically overexpressed in <i>mixed lineage leukemia</i> –rearranged leukemia
Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity
miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia
miR-495 is a tumor-suppressor microRNA down-regulated in <i>MLL</i> -rearranged leukemia