Area of research
Molecular Biology · Genetics
Research interest
Research interests include DNA Repair Mechanisms, Bacterial Genetics and Biotechnology, Genomics and Chromatin Dynamics, and DNA and Nucleic Acid Chemistry.
An explanation for origin unwinding in eukaryotes
Mcm10 has potent strand-annealing activity and limits translocase-mediated fork regression
Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks
Action of CMG with strand-specific DNA blocks supports an internal unwinding mode for the eukaryotic replicative helicase
Phosphorylation of CMG helicase and Tof1 is required for programmed fork arrest
Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation
Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork
CMG helicase and DNA polymerase ε form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication
Subunit sharing among high- and low-fidelity DNA polymerases