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Brian T. Chait

Rockefeller University · US
Area of research
Spectroscopy · Immunology
Research interest
and Laboratories Interdisciplinary Centers Clinical Research and the Rockefeller University Hospital Clinical Research Studies Scientific
h-index
129
citations
74,076
works
759
NIH funding
primary concept
Chemistry
email

Recent publications

Unique mechanisms to increase structural stability and enhance antigen binding in nanobodies
Structure 2025cited by 14position: middledoi
Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier
Nature Cell Biology 2025cited by 2position: middledoi
A Nature-Inspired Ion Trap for Parallel Manipulation of Ions on a Massive Scale
2025cited by 0position: selecteddoi
The molecular architecture of the nuclear basket
Cell 2024cited by 77position: middledoi
A new generation of nanobody research tools using improved mass spectrometry-based discovery methods
Journal of Biological Chemistry 2024cited by 11position: middledoi
Structural basis for substrate selection by the SARS-CoV-2 replicase
Nature 2023cited by 82position: middledoi
Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
Cancer Discovery 2023cited by 82position: middledoi
Implications of a multiscale structure of the yeast nuclear pore complex
Molecular Cell 2023cited by 24position: middledoi
Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain
Molecular Cell 2023cited by 21position: middledoi
Immunodominant surface epitopes power immune evasion in the African trypanosome
Cell Reports 2023cited by 14position: middledoi
Comprehensive structure and functional adaptations of the yeast nuclear pore complex
Cell 2022cited by 187position: middledoi
Shelterin is a dimeric complex with extensive structural heterogeneity
Proceedings of the National Academy of Sciences 2022cited by 45position: middledoi
Proteomic elucidation of the targets and primary functions of the picornavirus 2A protease
Journal of Biological Chemistry 2022cited by 25position: middledoi
Akey, C. et al. Comprehensive structure and functional adaptations of the yeast nuclear pore complex. Cell 185, 361–378 (2022).
2022cited by 0position: selected
Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis
Cell 2021cited by 334position: middledoi
Dynamic regulation of TFH selection during the germinal centre reaction
Nature 2021cited by 111position: middledoi
Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape
eLife 2021cited by 70position: middledoi
Analysis of the mechanosensor channel functionality of TACAN
eLife 2021cited by 37position: middledoi
Immunodominant surface epitopes power immune evasion in the African trypanosome
bioRxiv (Cold Spring Harbor Laboratory) 2021cited by 6position: middledoi
Mast, F. et al. Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape. Elife 10, e73027 (2021).
2021cited by 0position: selected
Integrative structure and function of the yeast exocyst complex
Protein Science 2020cited by 52position: middledoi
Structural basis of substrate recognition by a polypeptide processing and secretion transporter
eLife 2020cited by 35position: middledoi
Olinares, P.D.B. et al. Native mass spectrometry-based screening for optimal sample preparation in single-particle cryo-EM. Structure 29, 186–195 (2020).
2020cited by 0position: selected
Palaeoproteomics resolves sloth relationships
Nature Ecology & Evolution 2019cited by 131position: middledoi
Integrative structure and functional anatomy of a nuclear pore complex
Nature 2018cited by 546position: middledoi
Mcm10 has potent strand-annealing activity and limits translocase-mediated fork regression
Proceedings of the National Academy of Sciences 2018cited by 49position: middledoi
The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination
Molecular Cell 2018cited by 47position: middledoi
Integrative Structure and Functional Anatomy of a Nuclear Pore Complex
Microscopy and Microanalysis 2018cited by 11position: middledoi
Structure and Function of the Nuclear Pore Complex Cytoplasmic mRNA Export Platform
Cell 2016cited by 172position: middledoi
Proteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesis
Proceedings of the National Academy of Sciences 2016cited by 68position: middledoi

Grants

MASSBANK - A Protein Mass Spectrum Database
NSF9630936$260,0001996–1998PIRePORTER

Frequent collaborators

Michael P Rout · Rockefeller University16 papers (2012–2025)Andrej Săli · QB39 papers (2012–2025)Paul Dominic B. Olinares · Rockefeller University9 papers (2016–2023)Kelly R. Molloy · Rockefeller University7 papers (2013–2024)Javier Fernández-Martı́nez · Rockefeller University7 papers (2012–2025)Yi Shi · Hohai University7 papers (2015–2024)Peter C. Fridy · Rockefeller University5 papers (2014–2025)Junjie Wang · Rockefeller University4 papers (2016–2024)Michel C. Nussenzweig · Rockefeller University4 papers (2013–2021)Wenzhu Zhang · Rockefeller University4 papers (2012–2018)Ilona Nudelman · Rockefeller University4 papers (2014–2023)Yinyin Li · Qingdao Agricultural University3 papers (2014–2024)Sarah Keegan · New York University3 papers (2014–2024)John LaCava · New York University3 papers (2013–2015)Mary Kathryn Thompson · Technical University of Denmark3 papers (2014–2025)Thiago Y. Oliveira · Universidade de São Paulo3 papers (2013–2021)David Fenyö · Saint Louis University3 papers (2014–2024)Ignacia Echeverria · QB33 papers (2022–2024)Erica Y. Jacobs · Rockefeller University2 papers (2022–2024)F. Nina Papavasiliou · German Cancer Research Center2 papers (2021–2023)