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Darren Sigal

Scripps Health · US
Area of research
Pulmonary and Respiratory Medicine · Oncology
Research interest
Research interests include Lung Cancer Treatments and Mutations, Pancreatic and Hepatic Oncology Research, Cancer Genomics and Diagnostics, and Chronic Lymphocytic Leukemia Research.
h-index
23
citations
4,162
works
84
NIH funding
primary concept
Medicine
email

Recent publications

Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer
Cancer Cell 2022cited by 55position: middledoi
Randomized Phase III Trial of Pegvorhyaluronidase Alfa With Nab-Paclitaxel Plus Gemcitabine for Patients With Hyaluronan-High Metastatic Pancreatic Adenocarcinoma
Journal of Clinical Oncology 2020cited by 427position: middledoi
HALO 109-301: A randomized, double-blind, placebo-controlled, phase 3 study of pegvorhyaluronidase alfa (PEGPH20) + nab-paclitaxel/gemcitabine (AG) in patients (pts) with previously untreated hyaluronan (HA)-high metastatic pancreatic ductal adenocarcinoma (mPDA).
Journal of Clinical Oncology 2020cited by 110position: middledoi
Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1–2 trials
The Lancet Oncology 2019cited by 1,726position: middledoi
Entrectinib in NTRK fusion-positive non-small cell lung cancer (NSCLC): Integrated analysis of patients (pts) enrolled in STARTRK-2, STARTRK-1 and ALKA-372-001
Annals of Oncology 2019cited by 44position: middledoi
Efficacy and safety of entrectinib in patients with NTRK fusion-positive (NTRK-fp) Tumors: Pooled analysis of STARTRK-2, STARTRK-1 and ALKA-372-001
Annals of Oncology 2018cited by 64position: middledoi
HALO 202: Randomized Phase II Study of PEGPH20 Plus Nab-Paclitaxel/Gemcitabine Versus Nab-Paclitaxel/Gemcitabine in Patients With Untreated, Metastatic Pancreatic Ductal Adenocarcinoma
Journal of Clinical Oncology 2017cited by 480position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Collin M. Blakely · UCSF Helen Diller Family Comprehensive Cancer Center2 papers (2018–2019)Benjamin Besse · Institut Gustave Roussy2 papers (2018–2019)Andrew Hendifar · Stony Brook University2 papers (2017–2020)Robert C. Doebele · Institute of Biomedical Science2 papers (2018–2019)Diégo Tosi · Inserm2 papers (2018–2019)Stephen V. Liu · Georgetown University2 papers (2018–2019)Edna Chow‐Maneval · Georgetown University2 papers (2018–2019)Luis Paz‐Ares · Zhejiang Cancer Hospital2 papers (2018–2019)George D. Demetri · Harvard University2 papers (2018–2019)Anna F. Farago · Amgen (United States)2 papers (2018–2019)Takashi Seto · National Hospital Organization Kyushu Cancer Center2 papers (2018–2019)Andrea J. Bullock · Harvard University2 papers (2017–2020)Nathan Bahary · Allegheny Health Network2 papers (2017–2020)Sant P. Chawla · Sarcoma Oncology Center2 papers (2018–2019)Brian Simmons · Dartmouth Psychiatric Research Center2 papers (2018–2019)Lei Zheng · Fujian Medical University2 papers (2017–2020)John C. Krauss · Michigan Center for Translational Pathology2 papers (2018–2019)Giorgio Inghirami · Cornell University1 papers (2022–2022)María T. Díaz‐Meco · Cornell University1 papers (2022–2022)Andrea Wang‐Gillam · Washington University in St. Louis1 papers (2017–2017)