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Ernst‐Jan M. Speel

Maastricht University Medical Centre · NL
Area of research
Epidemiology · Oncology
Research interest
Research interests include Neuroendocrine Tumor Research Advances, Lung Cancer Research Studies, Head and Neck Cancer Studies, and Neuroblastoma Research and Treatments.
h-index
60
citations
12,541
works
354
NIH funding
primary concept
Medicine
email

Recent publications

Identification of Defined Molecular Subgroups on the Basis of Immunohistochemical Analyses and Potential Therapeutic Vulnerabilities of Pulmonary Carcinoids.
2025cited by 14position: contributordoi
<i>TERT</i> Expression and Clinical Outcome in Pulmonary Carcinoids.
2025cited by 10position: contributordoi
Exploring the antiproliferative effect of PI3K/Akt/mTOR pathway and CDK4/6 inhibitors in human papillomavirus‑positive and ‑negative head and neck squamous cell carcinoma cell lines.
2025cited by 4position: contributordoi
OTP, CD44, and Ki-67: A Prognostic Marker Panel for Relapse-Free Survival in Patients with Surgically Resected Pulmonary Carcinoid.
2025cited by 4position: contributordoi
The significance of <scp>PAX5</scp> in Merkel cell carcinoma
The Journal of Pathology 2025cited by 3position: middledoi
Frequent PD-L1 expression in oral squamous cell carcinoma of non-smokers and non-drinkers, and association of tumor infiltrating lymphocytes with favorable prognosis.
2025cited by 3position: contributordoi
Comprehensive Analysis of Neurogenic Differentiation Factor 1 (NEUROD1), Achaete-Scute Homolog 1 (ASCL1), POU Class 2 Homeobox 3 (POU2F3), and Yes-Associated Protein 1 (YAP1) Expression Signatures Reveals Unique Large-Cell Neuroendocrine Carcinoma (LCNEC) Subgroups With Potential Therapeutic Implications.
2025cited by 2position: contributordoi
Controversies in NEN: An ENETS position statement on the treatment of patients with Grade 3 well-differentiated neuroendocrine tumours of the gastro-enteropancreatic tract.
2025cited by 2position: contributordoi
Nationwide implementation and evaluation of the Tumor-First workflow for genetic testing in ovarian carcinoma.
2025cited by 2position: contributordoi
Clinical insight on the pathway of SLFN11 as emergent biomarker in SCLC.
2025cited by 1position: contributordoi
Deep Learning-Based Retinoblastoma Protein Subtyping of Pulmonary Large-Cell Neuroendocrine Carcinoma on Small Hematoxylin and Eosin-Stained Specimens.
2025cited by 1position: contributordoi
The significance of PAX5 in Merkel cell carcinoma.
2025cited by 1position: contributordoi
Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics.
2025cited by 1position: contributordoi
A Response to the Letter to the Editor: "Linear Versus Non-Linear: Debunking Critiques on PCA Use in Molecular Subgrouping of Pulmonary Carcinoids".
2025cited by 0position: contributordoi
Analytical Validation of a Pan-Cancer Next-Generation Sequencing Assay for In-House Liquid Biopsy Testing: An International Multicenter Study.
2025cited by 0position: contributordoi
Determining the optimal approach to identify osimertinib resistance; the first line osimertinib cohort of the OSIRIS study.
2025cited by 0position: contributordoi
Assessment of the current and emerging criteria for the histopathological classification of lung neuroendocrine tumours in the lungNENomics project
ESMO Open 2024cited by 16position: contributordoi
Disease relapse in relation to lymph node sampling in lung carcinoid patients.
2024cited by 5position: contributordoi
Abdominal inflammatory myofibroblastic tumour: Clinicopathological and molecular analysis of 20 cases, highlighting potential therapeutic targets.
2024cited by 4position: contributordoi
Radiological follow-up in patients with resected pulmonary carcinoids: Should we reduce radiation exposure?
2024cited by 3position: contributordoi
Next generation sequencing of high-grade adult-type diffuse glioma in the Netherlands: interlaboratory variation in the primary diagnostic and recurrent setting.
2024cited by 3position: contributordoi
Analytical Validation of a Pan-Cancer NGS Assay for In-House Liquid Biopsy Testing: An International Multicenter Study
2024cited by 2position: contributordoi
Mapping of Human Polyomavirus in Renal Cell Carcinoma Tissues.
2024cited by 2position: contributordoi
External Quality Assessment on Molecular Tumor Profiling with Circulating Tumor DNA-Based Methodologies Routinely Used in Clinical Pathology within the COIN Consortium.
2024cited by 2position: contributordoi
Proximity ligation-based sequencing for the identification of human papillomavirus genomic integration sites in formalin-fixed paraffin embedded oropharyngeal squamous cell carcinomas.
2024cited by 1position: contributordoi
RETRACTED: Characterization of therapeutic effects in Glioblastoma through integrated spatial single-cell multiome profiling of longitudinal samples: unveiling clinically relevant subtypes of pathological changes
2024cited by 0position: contributordoi
Detection of <i>PTCH1</i> Copy-Number Variants in Mosaic Basal Cell Nevus Syndrome.
2024cited by 0position: contributordoi
ROS1 fusions in resected stage I-III adenocarcinoma: Results from the European Thoracic Oncology Platform Lungscape project
Lung Cancer 2024cited by 0position: contributordoi
Druggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine neoplasms from multiple body sites
Cancer Cell 2023cited by 75position: middledoi
Druggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine neoplasms from multiple body sites.
2023cited by 55position: contributordoi

Grants

No grants ingested yet.

Frequent collaborators

· 24 papers (2019–2025)Jens Peter Klußmann · Düsseldorf University Hospital8 papers (2015–2023)Hendrikus J. Dubbink · Codarts Rotterdam8 papers (2019–2025)Ed Schuuring · Oncode Institute7 papers (2019–2024)Wim Timens · Rijnstate Hospital7 papers (2019–2025)Steffen Wagner · Justus-Liebig-Universität Gießen6 papers (2015–2023)S.P. Finn · Cancer Trials Ireland6 papers (2019–2024)Jan H. von der Thüsen · Erasmus MC5 papers (2019–2025)Imke Demers · Maastricht University Medical Centre5 papers (2020–2025) · 5 papers (2020–2021)Léon C. van Kempen · McGill University5 papers (2019–2024) · 5 papers (2020–2023)Egbert F. Smit · Groote Schuur Hospital4 papers (2019–2020)Solange Peters · Hôpital Beau-Séjour4 papers (2019–2021)Harry J.M. Groen · University Medical Center Groningen4 papers (2019–2021) · 4 papers (2019–2024)Anne‐Marie C. Dingemans · Erasmus University Rotterdam3 papers (2016–2025)Marjolijn J. L. Ligtenberg · ERN GENTURIS3 papers (2021–2025)Javier Hernández‐Losa · Centro de Investigación Biomédica en Red de Cáncer3 papers (2021–2024)Kim Monkhorst · Dutch Cancer Society3 papers (2021–2025)