Area of research
Genetics · Endocrinology, Diabetes and Metabolism
Research interest
Research interests include Genetic Associations and Epidemiology, Diabetes, Cardiovascular Risks, and Lipoproteins, Genetic Mapping and Diversity in Plants and Animals, and Genomics and Rare Diseases.
Accelerated Longitudinal Glycemic Changes in Relation to Urinary Toxic/Essential Metals and Metal Mixtures Among Mexican Americans Living in Starr County, Texas
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits
Global distributions of age- and sex-related arterial stiffness: systematic review and meta-analysis of 167 studies with 509,743 participants
Inferring compound heterozygosity from large-scale exome sequencing data
Relationships Between Urinary Metals and Diabetes Traits Among Mexican Americans in Starr County, Texas, USA
Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes
Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes
Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program
Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals
Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes
The effect of LRRK2 loss-of-function variants in humans
Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep
GWAS of QRS duration identifies new loci specific to Hispanic/Latino populations
A Genome-Wide Association Study Identifies Blood Disorder–Related Variants Influencing Hemoglobin A1c With Implications for Glycemic Status in U.S. Hispanics/Latinos
Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control
Admixture mapping identifies novel loci for obstructive sleep apnea in Hispanic/Latino Americans
Randomised clinical trial: faecal microbiota transplantation for recurrent <i>Clostridum difficile</i> infection – fresh, or frozen, or lyophilised microbiota from a small pool of healthy donors delivered by colonoscopy
Multiethnic Meta-Analysis Identifies <i>RAI1</i> as a Possible Obstructive Sleep Apnea–related Quantitative Trait Locus in Men
A Loss-of-Function Splice Acceptor Variant in <i>IGF2</i> Is Protective for Type 2 Diabetes
<i>FOXP3</i> mutations causing early‐onset insulin‐requiring diabetes but without other features of immune dysregulation, polyendocrinopathy, enteropathy, X‐linked syndrome
Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees
Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans
Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects and tissue-specific enrichment of eQTLs
Beyond type 2 diabetes, obesity and hypertension: an axis including sleep apnea, left ventricular hypertrophy, endothelial dysfunction, and aortic stiffness among Mexican Americans in Starr County, Texas
Variants in angiopoietin-2 (<i>ANGPT2</i>) contribute to variation in nocturnal oxyhaemoglobin saturation level
Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms
Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus
Continued lessons from the <i>INS</i> gene: an intronic mutation causing diabetes through a novel mechanism
Variants for HDL-C, LDL-C, and Triglycerides Identified from Admixture Mapping and Fine-Mapping Analysis in African American Families
Loss-of-function mutations in SLC30A8 protect against type 2 diabetes