Area of research
Surgery · Molecular Biology
Research interest
Research interests include Cholesterol and Lipid Metabolism, Peroxisome Proliferator-Activated Receptors, Drug Transport and Resistance Mechanisms, and Cancer, Lipids, and Metabolism.
Strategies for remote enantiocontrol in chiral gold(<scp>iii</scp>) complexes applied to catalytic enantioselective γ,δ-Diels–Alder reactions
IDOL regulates systemic energy balance through control of neuronal VLDLR expression
Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells
Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA
IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure
Parameterization of Acyclic Diaminocarbene Ligands Applied to a Gold(I)-Catalyzed Enantioselective Tandem Rearrangement/Cyclization
An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers
Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis
Cholesterol Accumulation in CD11c+ Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease
LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling
Thermoneutral Housing Accelerates Metabolic Inflammation to Potentiate Atherosclerosis but Not Insulin Resistance
Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis
The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Aβ amyloidosis
The Orphan Nuclear Receptor Nur77 Is a Determinant of Myofiber Size and Muscle Mass in Mice
Palmoplantar Keratoderma in Slurp2-Deficient Mice
Liver X receptors in lipid metabolism: opportunities for drug discovery
MafB promotes atherosclerosis by inhibiting foam-cell apoptosis
The LXR–Idol Axis Differentially Regulates Plasma LDL Levels in Primates and Mice
The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis
Transgenic Expression of Dominant-Active IDOL in Liver Causes Diet-Induced Hypercholesterolemia and Atherosclerosis in Mice
LXRs Regulate ER Stress and Inflammation through Dynamic Modulation of Membrane Phospholipid Composition
The nuclear receptor LXRα controls the functional specialization of splenic macrophages
Adipose Subtype-Selective Recruitment of TLE3 or Prdm16 by PPARγ Specifies Lipid Storage versus Thermogenic Gene Programs
IDOL Stimulates Clathrin-Independent Endocytosis and Multivesicular Body-Mediated Lysosomal Degradation of the Low-Density Lipoprotein Receptor
Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice
Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization
LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice