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David F. Claxton

Pennsylvania State University · US
Area of research
Hematology · Genetics
Research interest
Research interests include Medicine, Internal medicine, Myeloid leukemia, Tolerability, Adverse effect, and Discontinuation.
h-index
citations
1,972
works
20
NIH funding
primary concept
email

Recent publications

A randomized phase III study of standard versus high-dose cytarabine with or without vorinostat for AML
Leukemia 2023cited by 32position: middledoi
The impact of early PEG-asparaginase discontinuation in young adults with ALL: a post hoc analysis of the CALGB 10403 study
Blood Advances 2022cited by 14position: middledoi
HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia
Nature Communications 2021cited by 96position: middledoi
Comparison of CALGB 10403 (Alliance) and COG AALL0232 toxicity results in young adults with acute lymphoblastic leukemia
Blood Advances 2021cited by 50position: middledoi
Mechanistic Basis for In Vivo Therapeutic Efficacy of CK2 Inhibitor CX-4945 in Acute Myeloid Leukemia
Cancers 2021cited by 19position: middledoi
A pediatric regimen for older adolescents and young adults with acute lymphoblastic leukemia: results of CALGB 10403
Blood 2019cited by 465position: middledoi
Maintenance Decitabine (DAC) Improves Disease-Free (DFS) and Overall Survival (OS) after Intensive Therapy for Acute Myeloid Leukemia (AML) in Older Adults, Particularly in FLT3-ITD-Negative Patients: ECOG-ACRIN (E-A) E2906 Randomized Study
Blood 2019cited by 32position: middledoi
Selective inhibition of FLT3 by gilteritinib in relapsed or refractory acute myeloid leukaemia: a multicentre, first-in-human, open-label, phase 1–2 study
The Lancet Oncology 2017cited by 488position: middledoi
Outcomes of CLL patients treated with sequential kinase inhibitor therapy: a real world experience
Blood 2016cited by 188position: middledoi
SWOG S1203: A Randomized Phase III Study of Standard Cytarabine Plus Daunorubicin (7+3) Therapy Versus Idarubicin with High Dose Cytarabine (IA) with or without Vorinostat (IA+V) in Younger Patients with Previously Untreated Acute Myeloid Leukemia (AML)
Blood 2016cited by 59position: middledoi
Final Results of the Chrysalis Trial: A First-in-Human Phase 1/2 Dose-Escalation, Dose-Expansion Study of Gilteritinib (ASP2215) in Patients with Relapsed/Refractory Acute Myeloid Leukemia (R/R AML)
Blood 2016cited by 51position: middledoi
Importance of Achieving Complete Remission (CR) after Intensive Therapy for Acute Myeloid Leukemia (AML) in Older Adults Age ≥60 Years: Analysis of Risk Factors for Early Mortality and Re-Induction, and Impact of Quality of Response on Overall Survival (OS) in the ECOG-ACRIN E2906 Randomized Trial
Blood 2016cited by 7position: middledoi
Results of a first-in-human, phase I/II trial of ASP2215, a selective, potent inhibitor of FLT3/Axl in patients with relapsed or refractory (R/R) acute myeloid leukemia (AML).
Journal of Clinical Oncology 2015cited by 39position: middledoi
Antileukemic Activity and Tolerability of ASP2215 80mg and Greater in FLT3 Mutation-Positive Subjects with Relapsed or Refractory Acute Myeloid Leukemia: Results from a Phase 1/2, Open-Label, Dose-Escalation/Dose-Response Study
Blood 2015cited by 29position: middledoi
Favorable Outcomes in CLL Pts with Alternate Kinase Inhibitors Following Ibrutinib or Idelalisib Discontinuation: Results from a Large Multi-Center Study
Blood 2015cited by 17position: middledoi
Favorable Outcomes for Older Adolescents and Young Adults (AYA) with Acute Lymphoblastic Leukemia (ALL): Early Results of U.S. Intergroup Trial C10403
Blood 2014cited by 105position: middledoi
A Multicenter Phase I/II Study of Obatoclax Mesylate Administered as a 3- or 24-Hour Infusion in Older Patients with Previously Untreated Acute Myeloid Leukemia
PLoS ONE 2014cited by 77position: middledoi
Interim analysis of safety and efficacy of ruxolitinib in patients with myelofibrosis and low platelet counts
Journal of Hematology & Oncology 2013cited by 94position: middledoi
Frontline-Treatment Of Acute Lymphoblastic Leukemia (ALL) In Older Adolescents and Young Adults (AYA) Using a Pediatric Regimen Is Feasible: Toxicity Results of the Prospective US Intergroup Trial C10403 (Alliance)
Blood 2013cited by 47position: middledoi
Oral sapacitabine for the treatment of acute myeloid leukaemia in elderly patients: a randomised phase 2 study
The Lancet Oncology 2012cited by 63position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Selina M. Luger · Dana-Farber Cancer Institute9 papers (2012–2023)Harry P. Erba · Duke University9 papers (2013–2023)Mark R. Litzow · Mayo Clinic9 papers (2014–2023)Martin S. Tallman · Midwestern University7 papers (2013–2022)Stephen A. Strickland · Centennial Medical Center6 papers (2012–2023)Frederick R. Appelbaum · Fred Hutch Cancer Center6 papers (2013–2023)Richard M. Stone · Harvard University6 papers (2013–2023)Wendy Stock · Leukemia Research Foundation5 papers (2012–2022)Jessica K. Altman · Northwestern University5 papers (2015–2019)Matthew C. Foster · University of North Carolina at Chapel Hill4 papers (2013–2022)Gary J. Schiller · APLA Health4 papers (2012–2017)Anjali S. Advani · Cleveland Clinic4 papers (2013–2022)Michaela Liedtke · Stanford University4 papers (2013–2022)Bayard L. Powell · Atrium Medical Cente4 papers (2016–2023)Jörge E. Cortes · Cecil College3 papers (2015–2017)Alexander E. Perl · Hospital of the University of Pennsylvania3 papers (2015–2017)Eunice S. Wang · Roswell Park Comprehensive Cancer Center3 papers (2015–2017)Maria R. Baer · University of Pennsylvania3 papers (2015–2017)Guido Marcucci · City of Hope3 papers (2014–2023)Guillermo Garcia‐Manero · Cancer Clinic3 papers (2012–2023)