Area of research
Molecular Biology · Physiology
Research interest
Research interests include Muscle Physiology and Disorders, Adipose Tissue and Metabolism, Ion channel regulation and function, and Cardiomyopathy and Myosin Studies.
WNT-induced association of Frizzled and LRP6 is not sufficient for the initiation of WNT/β-catenin signaling
Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition
The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and remodeling
Stretch Harmonizes Sarcomere Strain Across the Cardiomyocyte
Orai1 as a potential “fits-all approach” therapeutic target for the treatment of DMD
Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
Exercise reduces intramuscular stress and counteracts muscle weakness in mice with breast cancer
Sphingomyelinase activity promotes atrophy and attenuates force in human muscle fibres and is elevated in heart failure patients
Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle
Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity
Intramuscular mechanisms of overtraining
Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance
Cartilage-binding antibodies induce pain through immune complex–mediated activation of neurons
Oxidative hotspots on actin promote skeletal muscle weakness in rheumatoid arthritis
Impaired sarcoplasmic reticulum Ca<sup>2+</sup> release is the major cause of fatigue‐induced force loss in intact single fibres from human intercostal muscle
LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force
Intact single muscle fibres from SOD1<sup>G93A</sup> amyotrophic lateral sclerosis mice display preserved specific force, fatigue resistance and training‐like adaptations
Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise
Post‐exercise recovery of contractile function and endurance in humans and mice is accelerated by heating and slowed by cooling skeletal muscle
Reactive oxygen/nitrogen species and contractile function in skeletal muscle during fatigue and recovery
Regulation of myogenesis and skeletal muscle regeneration: effects of oxygen levels on satellite cell activity
Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca <sup>2+</sup> leak after one session of high-intensity interval exercise
Antioxidant treatments do not improve force recovery after fatiguing stimulation of mouse skeletal muscle fibres
TNF- -mediated caspase-8 activation induces ROS production and TRPM2 activation in adult ventricular myocytes
Ryanodine Receptor Physiology and Its Role in Disease
AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation