Area of research
Molecular Biology · Biomedical Engineering
Research interest
Research interests include Muscle Physiology and Disorders, Muscle activation and electromyography studies, Exercise and Physiological Responses, and Cardiomyopathy and Myosin Studies.
New insights into the cellular and molecular mechanisms of skeletal muscle fatigue: the Marion J. Siegman Award Lectureships
Task-Dependent Mechanisms Underlying Prolonged Low-Frequency Force Depression
Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and remodeling
Sphingomyelinase activity promotes atrophy and attenuates force in human muscle fibres and is elevated in heart failure patients
Disruption of the microphysiological niche alters matrix deposition and causes loss of mitochondrial Ca <sup>2+</sup> control in skeletal muscle fibers
Carbohydrates do not accelerate force recovery after glycogen‐depleting followed by high‐intensity exercise in humans
Fast skeletal muscle troponin activator CK‐2066260 mitigates skeletal muscle weakness independently of the underlying cause
A Mechanism for Statin-Induced Susceptibility to Myopathy
Impaired sarcoplasmic reticulum Ca<sup>2+</sup> release is the major cause of fatigue‐induced force loss in intact single fibres from human intercostal muscle
Post‐exercise recovery of contractile function and endurance in humans and mice is accelerated by heating and slowed by cooling skeletal muscle
Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans
Reactive oxygen/nitrogen species and contractile function in skeletal muscle during fatigue and recovery
Acidosis Is Not a Significant Cause of Skeletal Muscle Fatigue
Mechanisms of force depression caused by different types of physical exercise studied by direct electrical stimulation of human quadriceps muscle
Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca <sup>2+</sup> leak after one session of high-intensity interval exercise
Antioxidant treatments do not improve force recovery after fatiguing stimulation of mouse skeletal muscle fibres
TNF- -mediated caspase-8 activation induces ROS production and TRPM2 activation in adult ventricular myocytes
Subcellular distribution of glycogen and decreased tetanic Ca<sup>2+</sup> in fatigued single intact mouse muscle fibres
Muscle glycogen stores and fatigue
Improved exercise performance and increased aerobic capacity after endurance training of patients with stable polymyositis and dermatomyositis
Dietary nitrate increases tetanic [Ca<sup>2+</sup>]<sub>i</sub> and contractile force in mouse fast‐twitch muscle
TLR4 as receptor for HMGB1 induced muscle dysfunction in myositis
Local Arginase Inhibition during Early Reperfusion Mediates Cardioprotection via Increased Nitric Oxide Production