Area of research
Molecular Biology
Research interest
Research interests include CRISPR and Genetic Engineering, Advanced biosensing and bioanalysis techniques, RNA and protein synthesis mechanisms, and RNA Interference and Gene Delivery.
CRISPR PERSIST-On enables heritable and fine-tunable human gene activation
MOSAIC enables
<i>in situ</i>
saturation mutagenesis of genes and CRISPR prime editing guide RNA optimization in human cells
Engineered CRISPR prime editors with compact, untethered reverse transcriptases.
Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state
Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state.
Genetic Predisposition to Neuroblastoma Results from a Regulatory Polymorphism that Promotes the Adrenergic Cell State
CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells.
Multidimensional control of therapeutic human cell function with synthetic gene circuits
Multidimensional control of therapeutic human cell function with synthetic gene circuits.
Author Correction: CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells.
Author Correction: Augmenting and directing long-range CRISPR-mediated activation in human cells.
CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells.
PrimeDesign software for rapid and simplified design of prime editing guide RNAs
Optimization of AsCas12a for combinatorial genetic screens in human cells.
PrimeDesign software for rapid and simplified design of prime editing guide RNAs.
Defining genome-wide CRISPR-Cas genome-editing nuclease activity with GUIDE-seq.
Scalable characterization of the PAM requirements of CRISPR–Cas enzymes using HT-PAMDA
Analysis of off-target effects in CRISPR-based gene drives in the human malaria mosquito
A Code of Ethics for Gene Drive Research
Augmenting and directing long-range CRISPR-mediated activation in human cells.
Analysis of off-target effects in CRISPR-based gene drives in the human malaria mosquito.
Global-scale CRISPR gene editor specificity profiling by ONE-seq identifies population-specific, variant off-target effects
CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells
Therapeutic base editing of human hematopoietic stem cells
A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing
Optimization of AsCas12a for combinatorial genetic screens in human cells
A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing.
PrimeDesign software for rapid and simplified design of prime editing guide RNAs
PrimeDesign software for rapid and simplified design of prime editing guide RNAs
CRISPResso2 provides accurate and rapid genome editing sequence analysis