Area of research
Molecular Biology · Genetics
Research interest
Research interests include CRISPR and Genetic Engineering, Virus-based gene therapy research, RNA and protein synthesis mechanisms, and Advanced biosensing and bioanalysis techniques.
Monitoring biological effects of somatic cell genome editing
Potent and uniform fetal hemoglobin induction via base editing
Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy
Base editing as a genetic treatment for spinal muscular atrophy
Base editing of haematopoietic stem cells rescues sickle cell disease in mice
The NIH Somatic Cell Genome Editing program
Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression
Prediction and validation of hematopoietic stem and progenitor cell off-target editing in transplanted rhesus macaques
Adenosine Base Editing of γ-Globin Promoters Induces Fetal Hemoglobin and Inhibit Erythroid Sickling
Base Editing Eliminates the Sickle Cell Mutation and Pathology in Hematopoietic Stem Cells Derived Erythroid Cells
Highly efficient therapeutic gene editing of human hematopoietic stem cells
High levels of AAV vector integration into CRISPR-induced DNA breaks
Zebrafish<i>dscaml1</i>Deficiency Impairs Retinal Patterning and Oculomotor Function
In vivo CRISPR editing with no detectable genome-wide off-target mutations
CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets
Nodal patterning without Lefty inhibitory feedback is functional but fragile
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells
Defining and improving the genome-wide specificities of CRISPR–Cas9 nucleases
Engineered CRISPR-Cas9 nucleases with altered PAM specificities
Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
Continuous directed evolution of DNA-binding proteins to improve TALEN specificity
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
Toddler: An Embryonic Signal That Promotes Cell Movement via Apelin Receptors
Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity
Efficient genome editing in zebrafish using a CRISPR-Cas system
Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins
FLASH assembly of TALENs for high-throughput genome editing
Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs