David Horn

Post-transcriptional reprogramming by thousands of mRNA untranslated regions in trypanosomes

Chemogenomic Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei

Insights into antitrypanosomal drug mode-of-action from cytology-based profiling

Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei

Ornithine uptake and the modulation of drug sensitivity in <i>Trypanosoma brucei</i>

Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs

VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes

Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression

Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes

Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes

Cathepsin-L Can Resist Lysis by Human Serum in Trypanosoma brucei brucei

Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

DNA Break Site at Fragile Subtelomeres Determines Probability and Mechanism of Antigenic Variation in African Trypanosomes

Cyclic AMP Effectors in African Trypanosomes Revealed by Genome-Scale RNA Interference Library Screening for Resistance to the Phosphodiesterase Inhibitor CpdA

Antigenic variation in<scp>A</scp>frican trypanosomes: the importance of chromosomal and nuclear context in<scp><i>VSG</i></scp>expression control

PPL2 Translesion Polymerase Is Essential for the Completion of Chromosomal DNA Replication in the African Trypanosome

Genetic dissection of drug resistance in trypanosomes

Receptor-mediated endocytosis for drug delivery in African trypanosomes: fulfilling Paul Ehrlich's vision of chemotherapy

High-throughput decoding of drug targets and drug resistance mechanisms in African trypanosomes

High-throughput decoding of antitrypanosomal drug efficacy and resistance

Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes

NUP-1 Is a Large Coiled-Coil Nucleoskeletal Protein in Trypanosomes with Lamin-Like Functions

Trypanosomal histone γH2A and the DNA damage response

Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei

Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei

Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes

Telomeres, tethers and trypanosomes