Area of research
Cardiology and Cardiovascular Medicine · Molecular Biology
Research interest
Research interests include Cardiomyopathy and Myosin Studies, Cardiovascular Effects of Exercise, Cardiac electrophysiology and arrhythmias, and Muscle Physiology and Disorders.
Hypercontractility and Oxidative Stress Drive Creatine Kinase Dysfunction in Hypertrophic Cardiomyopathy
Low expression of the K280N TNNT2 mutation is sufficient to increase basal myofilament activation in human hypertrophy cardiomyopathy
Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to<i>TTN</i>mutations
Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor
Interplay of sex hormones and long-term right ventricular adaptation in a Dutch PAH-cohort
Distinct hypertrophic cardiomyopathy genotypes result in convergent sarcomeric proteoform profiles revealed by top-down proteomics
Marked Up-Regulation of ACE2 in Hearts of Patients With Obstructive Hypertrophic Cardiomyopathy: Implications for SARS-CoV-2–Mediated COVID-19
Titin-truncating mutations associated with dilated cardiomyopathy alter length-dependent activation and its modulation via phosphorylation
Identification of <i>MYOM2</i> as a candidate gene in hypertrophic cardiomyopathy and Tetralogy of Fallot, and its functional evaluation in the <i>Drosophila</i> heart
The Translational Landscape of the Human Heart
PKC and PKN in heart disease
Prelamin A mediates myocardial inflammation in dilated and HIV-associated cardiomyopathies
Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy
A review of heavy metal cation binding to deoxyribonucleic acids for the creation of chemical sensors
Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct Sarcomeric Protein Isoforms
Monophosphorylation of cardiac troponin-I at Ser-23/24 is sufficient to regulate cardiac myofibrillar Ca2+ sensitivity and calpain-induced proteolysis
A model of cardiac contraction based on novel measurements of tension development in human cardiomyocytes
MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy
Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy
Increased collagen within the transverse tubules in human heart failure
Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes
The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease
Intrinsic MYH7 expression regulation contributes to tissue level allelic imbalance in hypertrophic cardiomyopathy
Myofilament Remodeling and Function Is More Impaired in Peripartum Cardiomyopathy Compared with Dilated Cardiomyopathy and Ischemic Heart Disease
Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes
Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth
MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy
Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy
Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca2+-sensitivity and suppress the modulation of Ca2+-sensitivity by troponin I phosphorylation
OBSCN Mutations Associated with Dilated Cardiomyopathy and Haploinsufficiency