Area of research
Cardiology and Cardiovascular Medicine · Molecular Biology
Research interest
Research interests include Cardiomyopathy and Myosin Studies, Cardiovascular Function and Risk Factors, Muscle Physiology and Disorders, and Cardiac electrophysiology and arrhythmias.
Early adjustments in mitochondrial structure and function in skeletal muscle to high altitude: design and rationale of the first study from the Kilimanjaro Biobank.
Inotropic interventions do not change the resting state of myosin motors during cardiac diastole.
Dysfunctional sarcomere contractility contributes to muscle weakness in <i>ACTA1</i>‐related nemaline myopathy (NEM3)
A 3D diffusional-compartmental model of the calcium dynamics in cytosol, sarcoplasmic reticulum and mitochondria of murine skeletal muscle fibers
Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill
The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease
Mutation‐specific effects on thin filament length in thin filament myopathy
Reduced force of diaphragm muscle fibers in patients with chronic thromboembolic pulmonary hypertension
Diaphragm Muscle Fiber Weakness and Ubiquitin–Proteasome Activation in Critically Ill Patients
Synergistic role of ADP and Ca<sup>2+</sup> in diastolic myocardial stiffness
Gene-specific increase in the energetic cost of contraction in hypertrophic cardiomyopathy caused by thick filament mutations
Contractile Dysfunction of Left Ventricular Cardiomyocytes in Patients With Pulmonary Arterial Hypertension
Faster cross‐bridge detachment and increased tension cost in human hypertrophic cardiomyopathy with the R403Q <i>MYH7</i> mutation
Protein Changes Contributing to Right Ventricular Cardiomyocyte Diastolic Dysfunction in Pulmonary Arterial Hypertension
Diaphragm Fiber Strength Is Reduced in Critically Ill Patients and Restored by a Troponin Activator
Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation
Right Ventricular Diastolic Impairment in Patients With Pulmonary Arterial Hypertension
Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy
Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy
Familial hypertrophic cardiomyopathy: Functional effects of myosin mutation R723G in cardiomyocytes
Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations
Mitochondrial Ca2+-Handling in Fast Skeletal Muscle Fibers from Wild Type and Calsequestrin-Null Mice
Titin-based stiffening of muscle fibers in Ehlers-Danlos Syndrome