Area of research
Molecular Biology · Cardiology and Cardiovascular Medicine
Research interest
Research interests include Muscle Physiology and Disorders, Cardiomyopathy and Myosin Studies, Respiratory Support and Mechanisms, and Cellular Mechanics and Interactions.
Super-relaxed myosins contribute to respiratory muscle hibernation in mechanically ventilated patients
Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function
Replacement Fibrosis in the Diaphragm of Mechanically Ventilated Critically Ill Patients
The HCM I79N pathogenic variant in cardiac TNT induces thick filament malfunction and myofilament lattice rearrangement
Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator
The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles
Pathogenic variants in TNNC2 cause congenital myopathy due to an impaired force response to calcium
Lung- and Diaphragm-Protective Ventilation
Diaphragm Pathology in Critically Ill Patients With COVID-19 and Postmortem Findings From 3 Medical Centers
Preserved single muscle fiber specific force in facioscapulohumeral muscular dystrophy
Osmotic Compression Influences Cross-Bridge Detachment Rate in Transgenic Hypertrophic Cardiomyopathy Variant Hctnt-I79N and Non-Transgenic Mouse Cardiac Muscle
LATE BREAKING NEWS ORAL PRESENTATION
KBTBD13 is an actin-binding protein that modulates muscle kinetics
Effects of levosimendan on respiratory muscle function in patients weaning from mechanical ventilation
Diaphragm contractile weakness due to reduced mechanical loading: role of titin
Positive End-Expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers
Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy
Titin‐based mechanosensing modulates muscle hypertrophy
Diaphragm plasticity in aging and disease: therapies for muscle weakness go from strength to strength
Dysfunctional sarcomere contractility contributes to muscle weakness in <i>ACTA1</i>‐related nemaline myopathy (NEM3)
Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill
Diaphragm-Protective Mechanical Ventilation to Improve Outcomes in ICU Patients?
Mutation‐specific effects on thin filament length in thin filament myopathy
Reduced force of diaphragm muscle fibers in patients with chronic thromboembolic pulmonary hypertension
Diaphragm Muscle Fiber Weakness and Ubiquitin–Proteasome Activation in Critically Ill Patients
Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy
Muscle weakness in<i>TPM3</i>-myopathy is due to reduced Ca<sup>2+</sup>-sensitivity and impaired acto-myosin cross-bridge cycling in slow fibres
Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy
Contractile Dysfunction of Left Ventricular Cardiomyocytes in Patients With Pulmonary Arterial Hypertension
Protein Changes Contributing to Right Ventricular Cardiomyocyte Diastolic Dysfunction in Pulmonary Arterial Hypertension