Area of research
Cardiology and Cardiovascular Medicine · Molecular Biology
Research interest
Research interests include Myosin, Sarcomere, Myosin head, Actin, Contractility, and Protein filament.
Myosin-binding protein C regulates the sarcomere lattice and stabilizes the OFF states of myosin heads
Super-relaxed myosins contribute to respiratory muscle hibernation in mechanically ventilated patients
Titin-Based Force Modulates Cardiac Thick and Thin Filaments
Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function
Disruption of Z-Disc Function Promotes Mechanical Dysfunction in Human Myocardium: Evidence for a Dual Myofilament Modulatory Role by Alpha-Actinin 2
Unlocking the Role of sMyBP-C: A Key Player in Skeletal Muscle Development and Growth
Molecular basis of force-pCa relation in <i>MYL2</i> cardiomyopathy mice: Role of the super-relaxed state of myosin
Myofibril orientation as a metric for characterizing heart disease
The HCM I79N pathogenic variant in cardiac TNT induces thick filament malfunction and myofilament lattice rearrangement
Fast skeletal myosin-binding protein-C regulates fast skeletal muscle contraction
Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility
MicroRNA-376b-3p targets RGS1 mRNA to inhibit proliferation, metastasis, and apoptosis in osteosarcoma
Pathogenic variants in TNNC2 cause congenital myopathy due to an impaired force response to calcium
Modulation of Cardiac Thin Filament Azimuthal Rigidity by Calcium and Cross-Bridges
Abstract P350: Myofibril Orientation In Cardiac Muscle And Its Implication For Heart Disease
Myofibril orientation as a metric for characterizing heart disease
Abstract P417: Cardiomyopathy-associated Variant In Troponin T Tail Domain Promotes Disruption Of Both Frank-starling Mechanism And Cardiac Myofilament Performance
Measurements of Actin Layer Lines in Permeabilized Heart Tissue Reveal New Structural Properties of the Cardiac Thin Filament
LATE BREAKING NEWS ORAL PRESENTATION
KBTBD13 is an actin-binding protein that modulates muscle kinetics
Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers
Thick-Filament Extensibility in Intact Skeletal Muscle
Nebulin stiffens the thin filament and augments cross-bridge interaction in skeletal muscle
Dysfunctional sarcomere contractility contributes to muscle weakness in <i>ACTA1</i>‐related nemaline myopathy (NEM3)
Structural and functional impact of troponin C-mediated Ca2+ sensitization on myofilament lattice spacing and cross-bridge mechanics in mouse cardiac muscle
Slow‐twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain
Cardiac Thin Filament-Mediated Calcium Sensitization Modulates Cross-Bridge Kinetics
Thin Filament-Mediated Modulation of Mouse Cardiac Cross-Bridge Kinetics by Ca 2+ -Sensitizing Mutation CTNC-A8V or Bepridil
The application of hydrogels to spinal cord injury