Area of research
Physiology · Rheumatology
Research interest
Research interests include Osteoclast, Adenosine, Chemistry, Cell biology, Bone resorption, and Medicine.
Novel alendronate-CGS21680 conjugate reduces bone resorption and induces new bone formation in post-menopausal osteoporosis and inflammatory osteolysis mouse models
Tenofovir Causes Bone Loss via Decreased Bone Formation and Increased Bone Resorption, Which Can Be Counteracted by Dipyridamole in Mice
Augmented Th17 Differentiation Leads to Cutaneous and Synovio‐Entheseal Inflammation in a Novel Model of Psoriatic Arthritis
Local delivery of adenosine receptor agonists to promote bone regeneration and defect healing
The antiviral drug tenofovir, an inhibitor of Pannexin-1-mediated ATP release, prevents liver and skin fibrosis by downregulating adenosine levels in the liver and skin
Immunotherapy Bridge 2016 and Melanoma Bridge 2016: meeting abstracts
Ticagrelor regulates osteoblast and osteoclast function and promotes bone formation in vivo <i>via</i> an adenosine‐dependent mechanism
Adenosine A<sub>2A</sub> receptor promotes collagen type III synthesis via β‐catenin activation in human dermal fibroblasts
Netrin‐1 and its receptor Unc5b are novel targets for the treatment of inflammatory arthritis
Bone regeneration in critical bone defects using three‐dimensionally printed β‐tricalcium phosphate/hydroxyapatite scaffolds is enhanced by coating scaffolds with either dipyridamole or BMP‐2
Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors
Netrin-1 is highly expressed and required in inflammatory infiltrates in wear particle-induced osteolysis
Adenosine A2A receptor plays an important role in radiation‐induced dermal injury
Netrin-1 Is a Critical Autocrine/Paracrine Factor for Osteoclast Differentiation
Activation of EPAC1/2 is essential for osteoclast formation by modulating NFκB nuclear translocation and actin cytoskeleton rearrangements
Brief Report: Methotrexate Prevents Wear Particle–Induced Inflammatory Osteolysis in Mice Via Activation of Adenosine A<sub>2A</sub> Receptor
Adenosine and bone metabolism
Activation of adenosine <scp>A<sub>2A</sub></scp> receptor reduces osteoclast formation via <scp>PKA</scp>‐ and <scp>ERK1</scp>/2‐mediated suppression of <scp>NF</scp>κ<scp>B</scp> nuclear translocation
Adenosine 2A receptor promotes collagen production by human fibroblasts <i>via</i> pathways involving cyclic AMP and AKT but independent of Smad2/3
Adenosine A2A receptor (A2AR) is a fine-tune regulator of the collagen1:collagen3 balance
Adenosine A<sub>2A</sub>Receptor Activation Prevents Wear Particle–Induced Osteolysis