Area of research
Pulmonary and Respiratory Medicine · Immunology
Research interest
Research interests include Aortic aneurysm repair treatments, Aortic Disease and Treatment Approaches, Axon Guidance and Neuronal Signaling, and Atherosclerosis and Cardiovascular Diseases.
Adenosine metabolism and receptors in aging of the skin, musculoskeletal, immune and cardiovascular systems
Region-specific gene expression and sex inform about disease susceptibility in the aorta
Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1
Fibrillin-1-regulated miR-122 has a critical role in thoracic aortic aneurysm formation
Chronic stress primes innate immune responses in mice and humans
Raman microspectroscopy and Raman imaging reveal biomarkers specific for thoracic aortic aneurysms
RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice
Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages
Circulating monocyte-platelet aggregates are a robust marker of platelet activity in cardiovascular disease
Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells
The long noncoding RNA CHROME regulates cholesterol homeostasis in primates
Platelet-Derived MRP-14 Induces Monocyte Activation in Patients With Symptomatic Peripheral Artery Disease
Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism
Modulation of ambient temperature promotes inflammation and initiates atherosclerosis in wild type C57BL/6 mice
miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux
Netrin‐1 and its receptor Unc5b are novel targets for the treatment of inflammatory arthritis
MicroRNA-33–dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis
Netrin-1 is highly expressed and required in inflammatory infiltrates in wear particle-induced osteolysis
Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity
Netrin-1 Is a Critical Autocrine/Paracrine Factor for Osteoclast Differentiation
CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
Hyperglycemia Promotes Myelopoiesis and Impairs the Resolution of Atherosclerosis
Endothelial Expression of Guidance Cues in Vessel Wall Homeostasis Dysregulation Under Proatherosclerotic Conditions
The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques