Area of research
Molecular Biology · Cardiology and Cardiovascular Medicine
Research interest
Research interests include Cardiomyopathy and Myosin Studies, Mitochondrial Function and Pathology, Protein Structure and Dynamics, and Signaling Pathways in Disease.
The mitochondrial calcium uniporter transports Ca
<sup>2+</sup>
via a ligand-relay mechanism
Congenital Hypermetabolism and Uncoupled Oxidative Phosphorylation
Congenital Hypermetabolism and Uncoupled Oxidative Phosphorylation.
MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations.
MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations
Crystal structure of MICU2 and comparison with MICU1 reveal insights into the uniporter gating mechanism
Crystal structure of MICU2 and comparison with MICU1 reveal insights into the uniporter gating mechanism.
Widespread Chromosomal Losses and Mitochondrial DNA Alterations as Genetic Drivers in Hürthle Cell Carcinoma
MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca <sup>2+</sup> and Mn <sup>2+</sup>
The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B12
High‐affinity cooperative Ca2+ binding by MICU1–MICU2 serves as an on–off switch for the uniporter
A genetically encoded tool for manipulation of NADP+/NADPH in living cells
Complementation of mitochondrial electron transport chain by manipulation of the NAD <sup>+</sup> /NADH ratio
Architecture of the mitochondrial calcium uniporter
CLYBL is a polymorphic human enzyme with malate synthase and β-methylmalate synthase activity