Area of research
Neurology · Molecular Biology
Research interest
Research interests include Neuroinflammation and Neurodegeneration Mechanisms, Ion channel regulation and function, Immune cells in cancer, and Pain Mechanisms and Treatments.
Microglia-mediated protection against Alzheimer’s disease pathology and detrimental effects in white matter revealed by Ptpn6 deletion
Neutral or Detrimental Effects of TREM2 Agonist Antibodies in Preclinical Models of Alzheimer’s Disease and Multiple Sclerosis
Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification
Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining
Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer’s disease
Disease-associated oligodendrocyte responses across neurodegenerative diseases
Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology
TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease
Neurotoxic reactive astrocytes are induced by activated microglia
New tools for studying microglia in the mouse and human CNS
X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel
Receptor-targeting mechanisms of pain-causing toxins: How ow?