Area of research
Physiology · Cellular and Molecular Neuroscience
Research interest
Research interests include Alzheimer's disease research and treatments, Neuroscience and Neuropharmacology Research, Parkinson's Disease Mechanisms and Treatments, and Mitochondrial Function and Pathology.
Integration across biophysical scales identifies molecular and cellular correlates of person-to-person variability in human brain connectivity
Distinct roles of <i>Bdnf I</i> and <i>Bdnf IV</i> transcript variant expression in hippocampal neurons
Dendritic spine head diameter predicts episodic memory performance in older adults
Integrated Proteomics to Understand the Role of Neuritin (NRN1) as a Mediator of Cognitive Resilience to Alzheimer’s Disease
Perspectives on ROCK2 as a Therapeutic Target for Alzheimer’s Disease
Conditional deletion of ROCK2 induces anxiety-like behaviors and alters dendritic spine density and morphology on CA1 pyramidal neurons
Dendritic Spines: Mediators of Cognitive Resilience in Aging and Alzheimer’s Disease
Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer’s Dementia
Dendritic Spine Remodeling and Synaptic Tau Levels in PS19 Tauopathy Mice
Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against β-amyloid
Fasudil or genetic depletion of ROCK1 or ROCK2 induces anxiety-like behaviors
α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons
Dendritic spine remodeling accompanies Alzheimer's disease pathology and genetic susceptibility in cognitively normal aging
Distinct and complementary functions of rho kinase isoforms ROCK1 and ROCK2 in prefrontal cortex structural plasticity
Dendritic spines provide cognitive resilience against <scp>A</scp>lzheimer's disease
Rho‐associated protein kinase 1 (<scp>ROCK</scp>1) is increased in Alzheimer's disease and <scp>ROCK</scp>1 depletion reduces amyloid‐β levels in brain
Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration
ROCK1 and ROCK2 inhibition alters dendritic spine morphology in hippocampal neurons
Pharmacologic Inhibition of ROCK2 Suppresses Amyloid-β Production in an Alzheimer's Disease Mouse Model
AAV2 production with optimized N/P ratio and PEI-mediated transfection results in low toxicity and high titer for in vitro and in vivo applications
Quantitative Analysis of the Detergent-Insoluble Brain Proteome in Frontotemporal Lobar Degeneration Using SILAC Internal Standards
Asparaginyl endopeptidase cleaves TDP‐43 in brain
GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production
Neuronal LR11 Expression Does Not Differentiate between Clinically-Defined Alzheimer's Disease and Control Brains