Area of research
Molecular Biology · Genetics
Research interest
Research interests include CRISPR and Genetic Engineering, Genomics and Chromatin Dynamics, Advanced biosensing and bioanalysis techniques, and RNA and protein synthesis mechanisms.
Prime assembly with linear DNA donors enables large genomic insertions.
Adissp activates insulin-independent glucose disposal and energy expenditure in white fat to treat diabetes and cardiometabolic disease.
SORT LNPs encapsulating Cas9 mRNA achieve efficient editing in skeletal muscle in a dystrophic mouse model
Systemic delivery of CRISPR-Cas9 nickase suppresses oncogene amplified cancer progression
Increasing intracellular dNTP levels improves prime editing efficiency.
Selective targeting of genome amplifications and repeat elements by CRISPR-Cas9 nickases to promote cancer cell death.
Direct delivery of Cas-embedded cytosine base editors as ribonucleoprotein complexes for efficient and accurate editing of clinically relevant targets.
Efficient Cas9 nuclease-based editing in skeletal muscle via lipid nanoparticle delivery
Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo.
Ex vivo culture resting time impacts transplantation outcomes of genome-edited human hematopoietic stem and progenitor cells in xenograft mouse models
Direct delivery of stabilized Cas-embedded base editors achieves efficient and accurate editing of clinically relevant targets
PRC1.6 localizes on chromatin with the human silencing hub (HUSH) complex for promoter-specific silencing
Human genetic diversity alters off-target outcomes of therapeutic gene editing.
Genome-wide profiling of prime editor off-target sites in vitro and in vivo using PE-tag
Genome-wide profiling of prime editor off-target sites in vitro and in vivo using PE-tag.
Reducing the inherent auto-inhibitory interaction within the pegRNA enhances prime editing efficiency.
Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing <i>in vivo</i>
Runx1-R188Q germ line mutation induces inflammation and predisposition to hematologic malignancies in mice.
Gene editing without
<i>ex vivo</i>
culture evades genotoxicity in human hematopoietic stem cells
Addressing the dNTP bottleneck restricting prime editing activity
Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing
<i>in vivo</i>
A brown fat-enriched adipokine, ASRA, is a leptin receptor antagonist that stimulates appetite
LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria.
A flexible split prime editor using truncated reverse transcriptase improves dual-AAV delivery in mouse liver.
Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors
Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors.
Genome-wide detection of CRISPR editing in vivo using GUIDE-tag.
Optimization of NLS Composition Improves CRISPR-Cas12a Editing Rates in Human Primary Cells
Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice.
The NIH Somatic Cell Genome Editing program