Area of research
Molecular Biology · Genetics
Research interest
Research interests include CRISPR and Genetic Engineering, Virus-based gene therapy research, Electrocatalysts for Energy Conversion, and Pluripotent Stem Cells Research.
In vivo genome editing of human haematopoietic stem cells for treatment of blood disorders using mRNA delivery.
In vivo base editing gene therapy for heterozygous familial hypercholesterolemia: a phase 1 trial.
CasY7: An optimized Cas12i system for enhanced genome editing in monocot crops.
Efficient and safe in vivo treatment of primary hyperoxaluria type 1 via LNP-CRISPR-Cas9-mediated glycolate oxidase disruption.
Spleen-targeted NeoPol-mL242 mRNA vaccine induces robust T-cell responses in a hepatocellular carcinoma model.
Sequential Amino Acid Mutagenesis-Driven De Novo Evolution of Adenine Deaminases Enables Efficient In Vivo Base Editing in Primate
Proteomic Profiling of Urinary Large Extracellular Vesicles for the Diagnosis of Prostate Cancer
Prdm12 governs an epigenetic checkpoint linking neuroimmune cross-talk to CD8<sup>+</sup> T cell exhaustion-suppressed antitumor immunity.
Genome editing or small molecule inhibition of KMT5A in CAR-T cells enhances antitumor immunity.
ATF7IP/SETDB1-mediated epigenetic programming regulates thymic homing and T lymphopoiesis of hematopoietic progenitors during embryogenesis.
Extracellular vesicle-derived miR-146a as a novel crosstalk mechanism for high-fat induced atherosclerosis by targeting SMAD4
Library-Assisted Evolution in Eukaryotic Cells Yield Adenine Base Editors with Enhanced Editing Specificity.
The Efficacy and Safety of Negative‐Pressure Wound Therapy Combined With Platelet‐Rich Plasma in Chronic Refractory Wounds: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials
Therapeutic adenine base editing of human hematopoietic stem cells.
Atf7ip and Setdb1 interaction orchestrates the hematopoietic stem and progenitor cell state with diverse lineage differentiation.
Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL.
CRISPR-Cas9-mediated gene editing of the BCL11A enhancer for pediatric β<sup>0</sup>/β<sup>0</sup> transfusion-dependent β-thalassemia.
Photoinduced Dual Shape Programmability of Covalent Adaptable Networks with Remarkable Mechanical Properties
Gonadal mosaicism mediated female-biased gender control in mice.
Improving GM and Tesla’s Declining Sales in China Based on SWOT Analysis
Efficient repair of human homozygous genetic mutation by CRISPR/Cas9 mediated interlocus gene conversion
Confining Zero‐Valent Platinum Single Atoms in α‐MoC<sub>1−</sub><i><sub>x</sub></i> for pH‐Universal Hydrogen Evolution Reaction
Computational Modeling of on-Flight COVID-19 Spread Incorporating Pedestrian Movement
Therapeutic base editing of human hematopoietic stem cells
Therapeutic base editing of human hematopoietic stem cells.
Dual base editor catalyzes both cytosine and adenine base conversions in human cells.
Highly efficient therapeutic gene editing of human hematopoietic stem cells
Highly efficient therapeutic gene editing of human hematopoietic stem cells.
Genome editing of HBG1 and HBG2 to induce fetal hemoglobin.
Editing aberrant splice sites efficiently restores β-globin expression in β-thalassemia