Area of research
Virology · Infectious Diseases
Research interest
Research interests include HIV Research and Treatment, HIV/AIDS drug development and treatment, Immune Cell Function and Interaction, and HIV/AIDS Research and Interventions.
Autologous neutralizing antibodies and polyfunctional T cells contribute to long-term HIV-1 post-intervention control
Decoding heterogeneous single-cell perturbation responses
Factors associated with resistance of HIV-1 reservoir viruses to neutralization by autologous IgG antibodies
Proviruses in CD4 <sup>+</sup> T cells reactive to autologous antigens contribute to nonsuppressible HIV-1 viremia
SIV proviruses seeded later in infection are harbored in short-lived CD4+ T cells
Superinfection promotes replication and diversification of defective HIV-1 proviruses in people with non-suppressible viraemia
Identifying correlates of viral rebound timing and viral control in SHIV-infected infant macaques after ART interruption
Mild HIV-specific selective forces overlaying natural CD4+ T cell dynamics explain the clonality and decay dynamics of HIV reservoir cells
Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells
Induction of durable remission by dual immunotherapy in SHIV-infected ART-suppressed macaques
HIV cure: The daunting scale of the problem
CD4+ T cells with latent HIV-1 have reduced proliferative responses to T cell receptor stimulation
Cognate antigen engagement induces HIV-1 expression in latently infected CD4+ T cells from people on long-term antiretroviral therapy
The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy
Clonally expanded HIV-1 proviruses with 5′-leader defects can give rise to nonsuppressible residual viremia
Antiretroviral therapy reveals triphasic decay of intact SIV genomes and persistence of ancestral variants
Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques
A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design
Measuring the latent reservoir for HIV-1: Quantification bias in near full-length genome sequencing methods
Genome-wide CRISPR screens identify combinations of candidate latency reversing agents for targeting the latent HIV-1 reservoir
Engaging innate immunity in HIV-1 cure strategies
In Vivo Dynamics of the Latent Reservoir for HIV-1: New Insights and Implications for Cure
Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption
Impact of Anti–PD-1 and Anti–CTLA-4 on the Human Immunodeficiency Virus (HIV) Reservoir in People Living With HIV With Cancer on Antiretroviral Therapy: The AIDS Malignancy Consortium 095 Study
Distinct viral reservoirs in individuals with spontaneous control of HIV-1
Differential decay of intact and defective proviral DNA in HIV-1–infected individuals on suppressive antiretroviral therapy
Antigen-driven clonal selection shapes the persistence of HIV-1–infected CD4+ T cells in vivo
Selective Decay of Intact HIV-1 Proviral DNA on Antiretroviral Therapy
Recommendations for measuring HIV reservoir size in cure-directed clinical trials
Intact proviral DNA assay analysis of large cohorts of people with HIV provides a benchmark for the frequency and composition of persistent proviral DNA