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Janet D. Siliciano

Howard Hughes Medical Institute · US
Area of research
Virology · Infectious Diseases
Research interest
Research interests include HIV Research and Treatment, HIV/AIDS drug development and treatment, Immune Cell Function and Interaction, and HIV/AIDS Research and Interventions.
h-index
70
citations
25,455
works
174
NIH funding
primary concept
Biology
email

Recent publications

Autologous neutralizing antibodies and polyfunctional T cells contribute to long-term HIV-1 post-intervention control
Nature Immunology 2026cited by 1position: middledoi
Decoding heterogeneous single-cell perturbation responses
Nature Cell Biology 2025cited by 21position: middledoi
Factors associated with resistance of HIV-1 reservoir viruses to neutralization by autologous IgG antibodies
Journal of Clinical Investigation 2025cited by 4position: middledoi
Proviruses in CD4 <sup>+</sup> T cells reactive to autologous antigens contribute to nonsuppressible HIV-1 viremia
Science Translational Medicine 2025cited by 3position: middledoi
SIV proviruses seeded later in infection are harbored in short-lived CD4+ T cells
Cell Reports 2025cited by 3position: middledoi
Superinfection promotes replication and diversification of defective HIV-1 proviruses in people with non-suppressible viraemia
Nature Microbiology 2025cited by 2position: middledoi
Identifying correlates of viral rebound timing and viral control in SHIV-infected infant macaques after ART interruption
Science Translational Medicine 2025cited by 2position: middledoi
Mild HIV-specific selective forces overlaying natural CD4+ T cell dynamics explain the clonality and decay dynamics of HIV reservoir cells
Cell Systems 2025cited by 1position: middledoi
Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells
Nature Immunology 2024cited by 42position: middledoi
Induction of durable remission by dual immunotherapy in SHIV-infected ART-suppressed macaques
Science 2024cited by 29position: middledoi
HIV cure: The daunting scale of the problem
Science 2024cited by 28position: firstdoi
CD4+ T cells with latent HIV-1 have reduced proliferative responses to T cell receptor stimulation
The Journal of Experimental Medicine 2024cited by 14position: middledoi
Cognate antigen engagement induces HIV-1 expression in latently infected CD4+ T cells from people on long-term antiretroviral therapy
Immunity 2024cited by 10position: middledoi
The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy
Journal of Clinical Investigation 2023cited by 127position: lastdoi
Clonally expanded HIV-1 proviruses with 5′-leader defects can give rise to nonsuppressible residual viremia
Journal of Clinical Investigation 2023cited by 90position: middledoi
Antiretroviral therapy reveals triphasic decay of intact SIV genomes and persistence of ancestral variants
Cell Host & Microbe 2023cited by 28position: middledoi
Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques
Immunity 2023cited by 23position: middledoi
A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design
The Journal of Experimental Medicine 2023cited by 12position: middledoi
Measuring the latent reservoir for HIV-1: Quantification bias in near full-length genome sequencing methods
PLoS Pathogens 2022cited by 55position: middledoi
Genome-wide CRISPR screens identify combinations of candidate latency reversing agents for targeting the latent HIV-1 reservoir
Science Translational Medicine 2022cited by 36position: middledoi
Engaging innate immunity in HIV-1 cure strategies
Nature reviews. Immunology 2021cited by 108position: lastdoi
In Vivo Dynamics of the Latent Reservoir for HIV-1: New Insights and Implications for Cure
Annual Review of Pathology Mechanisms of Disease 2021cited by 91position: firstdoi
Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption
Science Translational Medicine 2021cited by 81position: middledoi
Impact of Anti–PD-1 and Anti–CTLA-4 on the Human Immunodeficiency Virus (HIV) Reservoir in People Living With HIV With Cancer on Antiretroviral Therapy: The AIDS Malignancy Consortium 095 Study
Clinical Infectious Diseases 2021cited by 74position: middledoi
Distinct viral reservoirs in individuals with spontaneous control of HIV-1
Nature 2020cited by 417position: middledoi
Differential decay of intact and defective proviral DNA in HIV-1–infected individuals on suppressive antiretroviral therapy
JCI Insight 2020cited by 249position: middledoi
Antigen-driven clonal selection shapes the persistence of HIV-1–infected CD4+ T cells in vivo
Journal of Clinical Investigation 2020cited by 175position: middledoi
Selective Decay of Intact HIV-1 Proviral DNA on Antiretroviral Therapy
The Journal of Infectious Diseases 2020cited by 148position: middledoi
Recommendations for measuring HIV reservoir size in cure-directed clinical trials
Nature Medicine 2020cited by 136position: middledoi
Intact proviral DNA assay analysis of large cohorts of people with HIV provides a benchmark for the frequency and composition of persistent proviral DNA
Proceedings of the National Academy of Sciences 2020cited by 120position: lastdoi

Grants

No grants ingested yet.

Frequent collaborators

Robert F. Siliciano · University of Baltimore57 papers (2012–2025)Jun Lai · Xi'an Jiaotong University19 papers (2012–2025)Francesco R. Simonetti · Johns Hopkins University17 papers (2018–2025)Steven G. Deeks · University of California, San Francisco17 papers (2013–2025)Subul Beg · Johns Hopkins University12 papers (2017–2025)Rebecca Hoh · World Wide Web Consortium11 papers (2013–2025)Gregory M. Laird · CCC Diagnostics (United States)11 papers (2013–2020)Fengting Wu · Johns Hopkins University9 papers (2020–2025)Luis J. Montaner · The Wistar Institute8 papers (2018–2025)Adam A. Capoferri · Johns Hopkins University7 papers (2016–2019)Hao Zhang · The First People's Hospital of Shunde7 papers (2012–2025)Ya‐Chi Ho · Tzu Chi University7 papers (2013–2020)Christine M. Durand · National Institute of Allergy and Infectious Diseases7 papers (2012–2021)Daniel I. S. Rosenbloom · Columbia University6 papers (2013–2017)Milica Moskovljevic · Johns Hopkins Medicine6 papers (2021–2025)Emily J. Fray · Johns Hopkins University6 papers (2019–2025)Pablo Tebas · Presbyterian Hospital6 papers (2018–2025)Kyungyoon J. Kwon · Johns Hopkins University6 papers (2017–2020)Jennifer A. White · Palo Alto University6 papers (2018–2025)Joel N. Blankson · Office of AIDS Research5 papers (2013–2020)