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James P. Pirruccello

University of San Francisco · US
🔎 Find collaborators in Genetics · Pulmonary and Respiratory Medicine →
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Area of research
Genetics · Pulmonary and Respiratory Medicine
Research interest
Research interests include Genetic Associations and Epidemiology, Aortic Disease and Treatment Approaches, Aortic aneurysm repair treatments, and Cardiomyopathy and Myosin Studies.
h-index
44
citations
14,849
works
186
NIH funding
primary concept
Medicine
email

Recent publications

Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk
Nature Genetics 2025cited by 24position: middledoi
Unsupervised deep learning of electrocardiograms enables scalable human disease profiling
npj Digital Medicine 2025cited by 17position: middledoi
A deep learning digital biomarker to detect hypertension and stratify cardiovascular risk from the electrocardiogram
npj Digital Medicine 2025cited by 13position: middledoi
Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk
Nature Genetics 2025cited by 11position: middledoi
Electrocardiogram-Based Artificial Intelligence to Identify Coronary Artery Disease
JACC Advances 2025cited by 6position: middledoi
Pathogenic Cardiomyopathy-Associated Gene Variants and Prognosis in Atrial Fibrillation
Journal of the American College of Cardiology 2025cited by 4position: middledoi
Artificial Intelligence for Cardiovascular Care—Part 1: Advances
Journal of the American College of Cardiology 2024cited by 95position: middledoi
Associations of “Weekend Warrior” Physical Activity With Incident Disease and Cardiometabolic Health
Circulation 2024cited by 60position: middledoi
Artificial Intelligence in Cardiovascular Care—Part 2: Applications
Journal of the American College of Cardiology 2024cited by 59position: middledoi
Rare coding variant analysis for human diseases across biobanks and ancestries
Nature Genetics 2024cited by 54position: middledoi
Cardiovascular Significance and Genetics of Epicardial and Pericardial Adiposity
JAMA Cardiology 2024cited by 43position: middledoi
Clonal hematopoiesis, cardiovascular events and treatment benefit in 63,700 individuals from five TIMI randomized trials
Nature Medicine 2024cited by 37position: middledoi
Deep learning of left atrial structure and function provides link to atrial fibrillation risk
Nature Communications 2024cited by 33position: firstdoi
Noninvasive assessment of organ-specific and shared pathways in multi-organ fibrosis using T1 mapping
Nature Medicine 2024cited by 33position: middledoi
The AORTA Gene score for detection and risk stratification of ascending aortic dilation
European Heart Journal 2024cited by 20position: firstdoi
Rare Genetic Variants in <i>LDLR</i> , <i>APOB</i> , and <i>PCSK9</i> Are Associated With Aortic Stenosis
Circulation 2024cited by 17position: lastdoi
Molecular convergence of risk variants for congenital heart defects leveraging a regulatory map of the human fetal heart
medRxiv 2024cited by 11position: middledoi
Clonal haematopoiesis and risk of chronic liver disease
Nature 2023cited by 198position: middledoi
TP53-mediated clonal hematopoiesis confers increased risk for incident atherosclerotic disease
Nature Cardiovascular Research 2023cited by 126position: middledoi
Genetics of myocardial interstitial fibrosis in the human heart and association with disease
Nature Genetics 2023cited by 81position: middledoi
Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program
Nature Genetics 2023cited by 59position: middledoi
Adjusting for common variant polygenic scores improves yield in rare variant association analyses
Nature Genetics 2023cited by 45position: middledoi
Clinical and genetic associations of deep learning-derived cardiac magnetic resonance-based left ventricular mass
Nature Communications 2023cited by 42position: middledoi
The Genetic Determinants of Aortic Distention
Journal of the American College of Cardiology 2023cited by 33position: firstdoi
Exploring the complex spectrum of dominance and recessiveness in genetic cardiomyopathies
Nature Cardiovascular Research 2023cited by 32position: middledoi
Selenoprotein deficiency disorder predisposes to aortic aneurysm formation
Nature Communications 2023cited by 22position: middledoi
Author Correction: Clonal haematopoiesis and risk of chronic liver disease
Nature 2023cited by 2position: middledoi
Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank
Nature Genetics 2022cited by 173position: middledoi
Predictive Utility of a Coronary Artery Disease Polygenic Risk Score in Primary Prevention
JAMA Cardiology 2022cited by 127position: middledoi
Genetic analysis of right heart structure and function in 40,000 people
Nature Genetics 2022cited by 96position: firstdoi

Grants

No grants ingested yet.

Frequent collaborators

Patrick T. Ellinor · Icahn School of Medicine at Mount Sinai24 papers (2019–2025)Steven A. Lubitz · Boston Foundation13 papers (2019–2025)Shaan Khurshid · Broad Institute12 papers (2022–2025)Seung Hoan Choi · Boston University12 papers (2019–2025)Sam Friedman · Broad Institute11 papers (2020–2025)Joel Rämö · Institute for Molecular Medicine Finland10 papers (2023–2025)Sean J. Jurgens · Massachusetts Institute of Technology9 papers (2019–2025)Lu‐Chen Weng · Broad Institute9 papers (2019–2025)Anthony Philippakis · Broad Institute9 papers (2020–2025)Shinwan Kany · Broad Institute8 papers (2024–2025)Victor Nauffal · Massachusetts Institute of Technology7 papers (2022–2024)Puneet Batra · Broad Institute7 papers (2021–2025)Mahnaz Maddah · Massachusetts Institute of Technology6 papers (2024–2025)Mark Chaffin · Broad Institute5 papers (2019–2024)Kenney Ng · Cambridge Scientific (United States)5 papers (2020–2024)Kathryn L. Lunetta · Boston University5 papers (2019–2024)Carolina Roselli · Broad Institute5 papers (2019–2024)Jennifer E. Ho · S.P.E.C.I.E.S.5 papers (2023–2025)Paolo Di Achille · Broad Institute4 papers (2023–2025)Amit V. Khera · Institut universitaire de cardiologie et de pneumologie de Québec4 papers (2019–2021)
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