Area of research
Genetics · Surgery
Research interest
Research interests include Genetic Associations and Epidemiology, Lipoproteins and Cardiovascular Health, Diabetes, Cardiovascular Risks, and Lipoproteins, and Genomics and Rare Diseases.
High inherited risk predicts age-associated increases in fibrosis in patients with MASLD
Cardiovascular-Kidney-Metabolic Syndrome-Attributable Mortality in the United States, From 2010 to 2023
Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations
Familial Hypercholesterolemia Variant and Cardiovascular Risk in Individuals With Elevated Cholesterol
Physical Activity and Progression of Coronary Artery Calcification in Men and Women
A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease
Rare penetrant mutations confer severe risk of common diseases
South Asian medical cohorts reveal strong founder effects and high rates of homozygosity
Cardiovascular Disease Knowledge Portal: A Community Resource for Cardiovascular Disease Research
Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteins
Author Correction: A single-cell atlas of human and mouse white adipose tissue
Association of Severe Hypercholesterolemia and Familial Hypercholesterolemia Genotype With Risk of Coronary Heart Disease
Rare penetrant mutations confer severe risk of common diseases
Polygenic score informed by genome-wide association studies of multiple ancestries and related traits improves risk prediction for coronary artery disease
A single-cell atlas of human and mouse white adipose tissue
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease
Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation
Earlier treatment in adults with high lifetime risk of cardiovascular diseases: What prevention trials are feasible and could change clinical practice? Report of a National Heart, Lung, and Blood Institute (NHLBI) Workshop
Estimated Yield of Screening for Heterozygous Familial Hypercholesterolemia With and Without Genetic Testing in US Adults
Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease
Improving reporting standards for polygenic scores in risk prediction studies
Polygenic basis and biomedical consequences of telomere length variation
Association between adiposity and cardiovascular outcomes: an umbrella review and meta-analysis of observational and Mendelian randomization studies
Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease
Machine learning enables new insights into genetic contributions to liver fat accumulation
Author Correction: A structural variation reference for medical and population genetics
Lp(a) (Lipoprotein[a]) Concentrations and Incident Atherosclerotic Cardiovascular Disease
Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions